Angiosarcoma of the breast and vascular endothelial growth factor receptor

Massimiliano Gennaro, Barbara Valeri, Patrizia Casalini, Maria Luisa Carcangiu, Alessandro Gronchi, Alberto Rudy Conti, Roberto Agresti, Marco Greco

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Breast angiosarcoma is rare and often associated with previous breast cancer treatment. The present study aimed to define long-term outcomes in relation to common prognostic factors. The expression of vascular endothelial growth factor receptor was also evaluated, as it may be a potential target for anti-angiogenic therapy. Patients and methods. We retrospectively assessed outcomes in relation to age, association with previous breast-conserving treatment for breast cancer, tumor size, and grade in 19 patients without metastases at diagnosis. Vascular endothelial growth factor receptor was also assessed. Results. Median follow-up was 33 months (range, 1-121). There were 6 local recurrences and 6 deaths for disease progression. Five-year disease-free survival and overall survival were 53% (95% CI, 20-86%) and 49% (95% CI, 14-84%), respectively. No factor significantly affected survival. Vascular endothelial growth factor receptor was positive in 50% of cases and was more frequent in better differentiated cancer. Conclusions. The association of vascular endothelial growth factor receptor with G1/G2 tumors requires further investigations. Our findings suggest that anti-angiogenic treatment in vascular endothelial growth factor receptor-positive cases be considered as a novel therapeutic modality in this rare and aggressive disease. Although information is still incomplete, we propose a multimodal therapeutic approach including surgery, radiotherapy and chemotherapy. Free full text available at www.tumorionline.it.

Original languageEnglish
Pages (from-to)930-935
Number of pages6
JournalTumori
Volume96
Issue number6
Publication statusPublished - Nov 2010

Keywords

  • Breast angiosarcoma
  • Targeted therapy
  • VEGFR expression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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