Angiosarcoma of the breast, the unknown-a review of the current literature

Emanuela Esposito, Franca Avino, Raimondo di Giacomo, Ivana Donzelli, Ugo Marone, Maria Teresa Melucci, Chiara Rinaldo, Fulvio Ruffolo, Ruggero Saponara, Claudio Siani, Raffaele Tortoriello, Gerardo Botti, Massimo Rinaldo, Alfredo Fucito

Research output: Contribution to journalArticlepeer-review


Angiosarcoma of the breast is one of the rarest malignancies. Breast angiosarcoma can be classified into primary when arising de novo and secondary to chronic lymphoedema or breast irradiation. Molecular pathways involved in angiosarcoma development have not been described dearly, yet some gene point mutations and protein altered expression levels have been detected. So far, their management is based above all on surgery. Hence, further studies starting from the few known key points may help to develop more effective strategies based lx)th on target therapies, together with surgery.
Original languageEnglish
Pages (from-to)S510-S517
JournalTranslational Cancer Research
Issue number5
Publication statusPublished - Oct 1 2019


  • Angiosarcoma
  • breast
  • mesenchymal tumours


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