Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

Davide Seripa, Giulia Paroni, Maria G. Matera, Carolina Gravina, Carlo Scarcelli, Michele Corritore, Luigi P. D'Ambrosio, Maria Urbano, Grazia D'Onofrio, Massimiliano Copetti, Patrick G. Kehoe, Francesco Panza, Alberto Pilotto

Research output: Contribution to journalArticlepeer-review

Abstract

The association between angiotensinconverting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/ deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.

Original languageEnglish
Pages (from-to)409-419
Number of pages11
JournalAge
Volume33
Issue number3
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Aging
  • Angiotensin-converting enzyme
  • Disability
  • Hospitalized patients

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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