Abstract
The association between angiotensinconverting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/ deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.
| Original language | English |
|---|---|
| Pages (from-to) | 409-419 |
| Number of pages | 11 |
| Journal | Age |
| Volume | 33 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2011 |
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Keywords
- Aging
- Angiotensin-converting enzyme
- Disability
- Hospitalized patients
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
Cite this
Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients. / Seripa, Davide; Paroni, Giulia; Matera, Maria G.; Gravina, Carolina; Scarcelli, Carlo; Corritore, Michele; D'Ambrosio, Luigi P.; Urbano, Maria; D'Onofrio, Grazia; Copetti, Massimiliano; Kehoe, Patrick G.; Panza, Francesco; Pilotto, Alberto.
In: Age, Vol. 33, No. 3, 09.2011, p. 409-419.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients
AU - Seripa, Davide
AU - Paroni, Giulia
AU - Matera, Maria G.
AU - Gravina, Carolina
AU - Scarcelli, Carlo
AU - Corritore, Michele
AU - D'Ambrosio, Luigi P.
AU - Urbano, Maria
AU - D'Onofrio, Grazia
AU - Copetti, Massimiliano
AU - Kehoe, Patrick G.
AU - Panza, Francesco
AU - Pilotto, Alberto
PY - 2011/9
Y1 - 2011/9
N2 - The association between angiotensinconverting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/ deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.
AB - The association between angiotensinconverting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/ deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.
KW - Aging
KW - Angiotensin-converting enzyme
KW - Disability
KW - Hospitalized patients
UR - http://www.scopus.com/inward/record.url?scp=80655144819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80655144819&partnerID=8YFLogxK
U2 - 10.1007/s11357-010-9192-2
DO - 10.1007/s11357-010-9192-2
M3 - Article
C2 - 21076879
AN - SCOPUS:80655144819
VL - 33
SP - 409
EP - 419
JO - Age
JF - Age
SN - 0161-9152
IS - 3
ER -