TY - JOUR
T1 - Angiotensin-converting enzyme and adducin-1 polymorphisms in women with preeclampsia and gestational hypertension.
AU - Mandò, Chiara
AU - Antonazzo, Patrizio
AU - Tabano, Silvia
AU - Zanutto, Susanna
AU - Pileri, Paola
AU - Somigliana, Edgardo
AU - Colleoni, Francesca
AU - Martinelli, Anna
AU - Zolin, Anna
AU - Benedetto, Chiara
AU - Marozio, Luca
AU - Neri, Isabella
AU - Facchinetti, Fabio
AU - Miozzo, Monica
AU - Cetin, Irene
PY - 2009/9
Y1 - 2009/9
N2 - The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the Adducin-1 (ADD1) G460W nonsense single nucleotide polymorphism (SNP) have previously been associated to hypertension, whereas their association with preeclampsia (PE) and gestational hypertension (GH) is still controversial. We genotyped ACE I/D, ADD1 G460W, and ADD1 S586C polymorphisms in 672 unrelated pregnant women: 204 PE (81/204 mild PE), 56 GH, and 412 controls, evaluating both their single and combined effects on these pathologies. The genotype combination of the 3 polymorphisms was not statistically different in cases versus controls, nor were ACE and ADD1 polymorphisms in GH. Nevertheless, the distribution of ACE genotypes was different in PE. This was confirmed in mild PE, whereas no significance was found in severe PE. This could suggest that different factors may lead to mild and severe PE, with ACE polymorphism playing a more important role in the mild form.
AB - The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the Adducin-1 (ADD1) G460W nonsense single nucleotide polymorphism (SNP) have previously been associated to hypertension, whereas their association with preeclampsia (PE) and gestational hypertension (GH) is still controversial. We genotyped ACE I/D, ADD1 G460W, and ADD1 S586C polymorphisms in 672 unrelated pregnant women: 204 PE (81/204 mild PE), 56 GH, and 412 controls, evaluating both their single and combined effects on these pathologies. The genotype combination of the 3 polymorphisms was not statistically different in cases versus controls, nor were ACE and ADD1 polymorphisms in GH. Nevertheless, the distribution of ACE genotypes was different in PE. This was confirmed in mild PE, whereas no significance was found in severe PE. This could suggest that different factors may lead to mild and severe PE, with ACE polymorphism playing a more important role in the mild form.
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M3 - Article
C2 - 19443911
AN - SCOPUS:70350732618
VL - 16
SP - 819
EP - 826
JO - Reproductive Sciences
JF - Reproductive Sciences
SN - 1933-7191
IS - 9
ER -