Angiotensin-converting enzyme and endothelial nitric oxide synthase polymorphisms in patients with atrial fibrillation

Francesca Gensini, Luigi Padeletti, Cinzia Fatini, Elena Sticchi, Gian Franco Gensini, Antonio Michelucci

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental studies have shown a significant increase in angiotensin-converting enzyme (ACE) expression in atrial tissue of AF patients. ACE regulates the synthesis of endothelial nitric oxide (NO), which modulates autonomic nervous activity involved in the development of AF. The aim of the study was to evaluate the prevalence of ACE insertion/deletion and endothelial NO synthase (eNOS) T-786C, G894T, and 4a/4b polymorphisms in 148 patients with persistent AF, compared with 210 control subjects. ACE insertion/deletion polymorphism genotype distribution and allele frequency were significantly different between patients and controls (P <0.0001 and P <0.0001, respectively). ACE DD genotype was significantly associated with the risk of AF (OR DD/ID + II = 3.24, P <0.0001). Analysis of eNOS polymorphisms showed no significant difference in genotype distribution and allele frequency between patients and controls. The results suggest a possible role of ACE DD genotype as a predisposing factor to AF and a pathophysiological mechanism of ACE inhibition in reducing the incidence of AF in patients with left ventricular dysfunction.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalPACE - Pacing and Clinical Electrophysiology
Volume26
Issue number1 II
Publication statusPublished - Jan 1 2003

Keywords

  • Angiotensin-converting enzyme
  • Atrial fibrillation
  • Endothelial nitric oxide synthase
  • Genetic polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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