Angiotensin-converting enzyme ins/del polymorphism and body composition: The intermediary role of hydration status

Laura Bordoni, Valerio Napolioni, Francesca Marchegiani, Emilio Amadio, Rosita Gabbianelli

Research output: Contribution to journalArticle


Background: The well-known insertion/deletion polymorphism (rs4646994) of the angiotensin-converting enzyme (ACE) gene has been previously associated with obesity, blood flow, muscular strength, and ACE enzyme activity. Despite the relevant role of ACE in homeostasis, few data are currently available on the relationship between rs4646994 and hydration status. Thus, we tested the association between the ACE Ins/Del polymorphism, body composition, and hydration status in a young Italian population. Methods: A total of 306 healthy children and adolescents who regularly practice sports were recruited. Anthropometric, bioimpedentiometric parameters, and urine samples were collected, while ACE rs4646994 genotyping was performed on DNA from buccal swabs. General linear models were used for association testing. Results: The ACE Ins/Del polymorphism was associated with body composition. Ins/Ins individuals had higher phase angle (PhA) and body cellular mass index (BCMI) values. A significant influence of the ACE rs4646994 according to hydration status on body composition was also identified. In particular, Ins/Ins individuals displayed higher PhA and BCMI values only if norm-hydrated, while they showed values similar to Del carriers if dehydrated. Conclusion: Our results confirm the relationship between the ACE Ins/Del polymorphism and body composition and suggest a role for hydration status in modulating this relationship. These interesting preliminary results warrant further investigation to disentangle the genetic role of ACE on hydration homeostasis.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Nutrigenetics and Nutrigenomics
Issue number1-2
Publication statusPublished - Aug 1 2017


  • Angiotensin-converting enzyme gene
  • Body cellular mass index
  • Body composition
  • Hydration - Urine specific gravity
  • Phase angle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Genetics

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