Angiotensin-converting enzyme insertion/deletion gene polymorphism in inflammatory bowel diseases

Simone Saibeni, Luisa Spina, Tiziana Virgilio, Anna Folcioni, Greta Borsi, Roberto De Franchis, Massimo Cugno, Maurizio Vecchi

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: The renin-angiotensin system is strictly related to the kallikrein-kinin system and both are involved in many physiological and disease conditions and possibly in the pathogenesis of inflammatory bowel disease (IBD). Angiotensin-converting enzyme (ACE) is the pivotal enzyme of the renin-angiotensin system and the main catabolic enzyme of the kallikrein-kinin system. The ACE I/D (insertion/deletion) is a polymorphism of the gene encoding for ACE: participants who are homozygous for the D allele exhibit higher ACE levels, which in turn appear to play a deleterious role in several diseases. AIM: To study the prevalence of ACE I/D polymorphism in IBD patients and its possible association with disease features. METHODS: A total of 232 IBD patients, 124 with ulcerative colitis (UC) and 108 with Crohn's disease and 99 healthy controls were genotyped for the ACE I/D polymorphism. RESULTS: DD, ID and II genotypes distribution did not show significant differences between IBD patients and controls: 42.2 vs. 40.4%, 42.7 vs. 47.5% and 15.1 vs. 12.1%, respectively. No significant difference was observed between Crohn's disease and UC patients. Within UC patients, the presence of DD genotype and the carriage of the D allele were significantly associated with the presence of extraintestinal manifestations: odds ratio (OR) 4.08, 95% confidence interval (CI): 1.62-10.28; P

Original languageEnglish
Pages (from-to)976-981
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume19
Issue number11
DOIs
Publication statusPublished - Nov 2007

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Keywords

  • Angiotensin-converting enzyme
  • Extraintestinal manifestations
  • Gene polymorphism
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Gastroenterology

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