Abstract
The D allele of the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is associated with higher plasma and tissue ACE levels, which enhance the stimulus for neo-intimal hyperplasia. Plaque debulking before stenting reduces the plaque-related determinants of in-stent restenosis and provides an ideal clinical model for studying neo-intimal hyperplasia. We prospectively studied 113 consecutive patients undergoing elective DCA followed by stent implantation. The presence of I/D in ACE genome DNA was analysed by means of polymerase chain reaction. Follow-up coronary angiography was performed 6-12 months after DCA, and all of the angiograms were quantitatively analysed.The baseline clinical and angiographic characteristics of the patients with a D/D (33%), I/D (52%) and 1/1 (15%) genotype were well balanced. There were no significant differences in minimal lumen diameter before and after the procedure or at follow-up, and no significant differences in acute gain, late loss or the loss index. Our results indicate that ACE I/D polymorphism does not influence the risk of developing angiographic restenosis in patients undergoing DCA followed by stent implantation.
| Original language | English |
|---|---|
| Pages (from-to) | 795-800 |
| Number of pages | 6 |
| Journal | Thrombosis and Haemostasis |
| Volume | 91 |
| Issue number | 4 |
| Publication status | Published - Apr 2004 |
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Keywords
- ACE-gene polymorphism
- Directional coronary atherectomy
- Restenosis
- Stent
ASJC Scopus subject areas
- Hematology
Cite this
Angiotensin-converting enzyme insertion/deletion polymorphism and risk of restenosis after directional coronary atherectomy followed by stent implanatation. / Canosi, Umberto; Merlini, Piera Angelica; Bernardi, Francesco; Repetto, Alessandra; Bramucci, Ezio; Ferrario, Maurizio; Angoli, Luigi; Gnecchi, Massimiliano; Ferraresi, Paolo; Marchetti, Giovanna; Tavazzi, Luigi; Ardissino, Diego.
In: Thrombosis and Haemostasis, Vol. 91, No. 4, 04.2004, p. 795-800.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiotensin-converting enzyme insertion/deletion polymorphism and risk of restenosis after directional coronary atherectomy followed by stent implanatation
AU - Canosi, Umberto
AU - Merlini, Piera Angelica
AU - Bernardi, Francesco
AU - Repetto, Alessandra
AU - Bramucci, Ezio
AU - Ferrario, Maurizio
AU - Angoli, Luigi
AU - Gnecchi, Massimiliano
AU - Ferraresi, Paolo
AU - Marchetti, Giovanna
AU - Tavazzi, Luigi
AU - Ardissino, Diego
PY - 2004/4
Y1 - 2004/4
N2 - The D allele of the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is associated with higher plasma and tissue ACE levels, which enhance the stimulus for neo-intimal hyperplasia. Plaque debulking before stenting reduces the plaque-related determinants of in-stent restenosis and provides an ideal clinical model for studying neo-intimal hyperplasia. We prospectively studied 113 consecutive patients undergoing elective DCA followed by stent implantation. The presence of I/D in ACE genome DNA was analysed by means of polymerase chain reaction. Follow-up coronary angiography was performed 6-12 months after DCA, and all of the angiograms were quantitatively analysed.The baseline clinical and angiographic characteristics of the patients with a D/D (33%), I/D (52%) and 1/1 (15%) genotype were well balanced. There were no significant differences in minimal lumen diameter before and after the procedure or at follow-up, and no significant differences in acute gain, late loss or the loss index. Our results indicate that ACE I/D polymorphism does not influence the risk of developing angiographic restenosis in patients undergoing DCA followed by stent implantation.
AB - The D allele of the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is associated with higher plasma and tissue ACE levels, which enhance the stimulus for neo-intimal hyperplasia. Plaque debulking before stenting reduces the plaque-related determinants of in-stent restenosis and provides an ideal clinical model for studying neo-intimal hyperplasia. We prospectively studied 113 consecutive patients undergoing elective DCA followed by stent implantation. The presence of I/D in ACE genome DNA was analysed by means of polymerase chain reaction. Follow-up coronary angiography was performed 6-12 months after DCA, and all of the angiograms were quantitatively analysed.The baseline clinical and angiographic characteristics of the patients with a D/D (33%), I/D (52%) and 1/1 (15%) genotype were well balanced. There were no significant differences in minimal lumen diameter before and after the procedure or at follow-up, and no significant differences in acute gain, late loss or the loss index. Our results indicate that ACE I/D polymorphism does not influence the risk of developing angiographic restenosis in patients undergoing DCA followed by stent implantation.
KW - ACE-gene polymorphism
KW - Directional coronary atherectomy
KW - Restenosis
KW - Stent
UR - http://www.scopus.com/inward/record.url?scp=11144354421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144354421&partnerID=8YFLogxK
M3 - Article
C2 - 15045142
AN - SCOPUS:11144354421
VL - 91
SP - 795
EP - 800
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 4
ER -