Angiotensin-converting enzyme insertion/deletion polymorphism and risk of restenosis after directional coronary atherectomy followed by stent implanatation

Umberto Canosi, Piera Angelica Merlini, Francesco Bernardi, Alessandra Repetto, Ezio Bramucci, Maurizio Ferrario, Luigi Angoli, Massimiliano Gnecchi, Paolo Ferraresi, Giovanna Marchetti, Luigi Tavazzi, Diego Ardissino

Research output: Contribution to journalArticle

Abstract

The D allele of the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is associated with higher plasma and tissue ACE levels, which enhance the stimulus for neo-intimal hyperplasia. Plaque debulking before stenting reduces the plaque-related determinants of in-stent restenosis and provides an ideal clinical model for studying neo-intimal hyperplasia. We prospectively studied 113 consecutive patients undergoing elective DCA followed by stent implantation. The presence of I/D in ACE genome DNA was analysed by means of polymerase chain reaction. Follow-up coronary angiography was performed 6-12 months after DCA, and all of the angiograms were quantitatively analysed.The baseline clinical and angiographic characteristics of the patients with a D/D (33%), I/D (52%) and 1/1 (15%) genotype were well balanced. There were no significant differences in minimal lumen diameter before and after the procedure or at follow-up, and no significant differences in acute gain, late loss or the loss index. Our results indicate that ACE I/D polymorphism does not influence the risk of developing angiographic restenosis in patients undergoing DCA followed by stent implantation.

Original languageEnglish
Pages (from-to)795-800
Number of pages6
JournalThrombosis and Haemostasis
Volume91
Issue number4
Publication statusPublished - Apr 2004

Keywords

  • ACE-gene polymorphism
  • Directional coronary atherectomy
  • Restenosis
  • Stent

ASJC Scopus subject areas

  • Hematology

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    Canosi, U., Merlini, P. A., Bernardi, F., Repetto, A., Bramucci, E., Ferrario, M., Angoli, L., Gnecchi, M., Ferraresi, P., Marchetti, G., Tavazzi, L., & Ardissino, D. (2004). Angiotensin-converting enzyme insertion/deletion polymorphism and risk of restenosis after directional coronary atherectomy followed by stent implanatation. Thrombosis and Haemostasis, 91(4), 795-800.