TY - JOUR
T1 - Angiotensin-converting enzyme insertion/deletion polymorphism and risk of restenosis after directional coronary atherectomy followed by stent implanatation
AU - Canosi, Umberto
AU - Merlini, Piera Angelica
AU - Bernardi, Francesco
AU - Repetto, Alessandra
AU - Bramucci, Ezio
AU - Ferrario, Maurizio
AU - Angoli, Luigi
AU - Gnecchi, Massimiliano
AU - Ferraresi, Paolo
AU - Marchetti, Giovanna
AU - Tavazzi, Luigi
AU - Ardissino, Diego
PY - 2004/4
Y1 - 2004/4
N2 - The D allele of the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is associated with higher plasma and tissue ACE levels, which enhance the stimulus for neo-intimal hyperplasia. Plaque debulking before stenting reduces the plaque-related determinants of in-stent restenosis and provides an ideal clinical model for studying neo-intimal hyperplasia. We prospectively studied 113 consecutive patients undergoing elective DCA followed by stent implantation. The presence of I/D in ACE genome DNA was analysed by means of polymerase chain reaction. Follow-up coronary angiography was performed 6-12 months after DCA, and all of the angiograms were quantitatively analysed.The baseline clinical and angiographic characteristics of the patients with a D/D (33%), I/D (52%) and 1/1 (15%) genotype were well balanced. There were no significant differences in minimal lumen diameter before and after the procedure or at follow-up, and no significant differences in acute gain, late loss or the loss index. Our results indicate that ACE I/D polymorphism does not influence the risk of developing angiographic restenosis in patients undergoing DCA followed by stent implantation.
AB - The D allele of the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is associated with higher plasma and tissue ACE levels, which enhance the stimulus for neo-intimal hyperplasia. Plaque debulking before stenting reduces the plaque-related determinants of in-stent restenosis and provides an ideal clinical model for studying neo-intimal hyperplasia. We prospectively studied 113 consecutive patients undergoing elective DCA followed by stent implantation. The presence of I/D in ACE genome DNA was analysed by means of polymerase chain reaction. Follow-up coronary angiography was performed 6-12 months after DCA, and all of the angiograms were quantitatively analysed.The baseline clinical and angiographic characteristics of the patients with a D/D (33%), I/D (52%) and 1/1 (15%) genotype were well balanced. There were no significant differences in minimal lumen diameter before and after the procedure or at follow-up, and no significant differences in acute gain, late loss or the loss index. Our results indicate that ACE I/D polymorphism does not influence the risk of developing angiographic restenosis in patients undergoing DCA followed by stent implantation.
KW - ACE-gene polymorphism
KW - Directional coronary atherectomy
KW - Restenosis
KW - Stent
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M3 - Article
C2 - 15045142
AN - SCOPUS:11144354421
VL - 91
SP - 795
EP - 800
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 4
ER -