Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses

M. Volpe, S. A. Atlas, R. E. Sosa, D. E. Marion, F. B. Mueller, J. E. Sealey, J. H. Laragh

Research output: Contribution to journalArticle

Abstract

Angiotensin II (Ang II) and atrial natriuretic factor (ANF) appear to act as functional antagonists in the regulation of fluid and electrolyte homeostasis and blood pressure. To further define the relations between these hormones in vivo, we investigated the effect of low doses of Ang II (1-10 ng/kg/min) on plasma ANF levels. We also evaluated the influence of ANF release on the renal and hormonal responses to Ang II. Studies were performed in anesthetized and conscious instrumented dogs during sustained saline load and converting enzyme inhibition. In the anesthetized dogs, Ang II significantly increased plasma ANF levels and ANF arteriovenous difference without changing either atrial pressures or hematocrit. In both conscious and anesthetized dogs, ANF increases were not correlated with blood pressure responses to Ang II and did not occur in control groups when Ang II was replaced by vehicle. Ang II-induced sodium retention and stimulation of aldosterone production were attenuated, and renin suppression was enhanced in dogs having the largest changes in plasma ANF in response to converting enzyme inhibition or Ang II. These results demonstrate that in volume-replete dogs Ang II can promote ANF release independently of changes in atrial pressures or systemic hemodynamics, suggesting that Ang II may exert a significantly modulatory effect on ANF secretion. The results also show significant relations between ANF and renal and adrenal responses to Ang II, which may suggest that, in turn, endogenous ANF modulates the effects of Ang II.

Original languageEnglish
Pages (from-to)774-779
Number of pages6
JournalCirculation Research
Volume67
Issue number3
Publication statusPublished - 1990

Fingerprint

Atrial Natriuretic Factor
Angiotensin II
Hemodynamics
Dogs
Atrial Pressure
Blood Pressure
Kidney
Enzymes
Aldosterone
Hematocrit
Renin
Electrolytes
Homeostasis
Sodium
Hormones

Keywords

  • body fluid homeostasis
  • hemodynamics
  • kidney
  • renin-angiotensin-aldosterone system

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Volpe, M., Atlas, S. A., Sosa, R. E., Marion, D. E., Mueller, F. B., Sealey, J. E., & Laragh, J. H. (1990). Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses. Circulation Research, 67(3), 774-779.

Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses. / Volpe, M.; Atlas, S. A.; Sosa, R. E.; Marion, D. E.; Mueller, F. B.; Sealey, J. E.; Laragh, J. H.

In: Circulation Research, Vol. 67, No. 3, 1990, p. 774-779.

Research output: Contribution to journalArticle

Volpe, M, Atlas, SA, Sosa, RE, Marion, DE, Mueller, FB, Sealey, JE & Laragh, JH 1990, 'Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses', Circulation Research, vol. 67, no. 3, pp. 774-779.
Volpe, M. ; Atlas, S. A. ; Sosa, R. E. ; Marion, D. E. ; Mueller, F. B. ; Sealey, J. E. ; Laragh, J. H. / Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses. In: Circulation Research. 1990 ; Vol. 67, No. 3. pp. 774-779.
@article{aca894a562ac4b85b594aa785176e4ef,
title = "Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses",
abstract = "Angiotensin II (Ang II) and atrial natriuretic factor (ANF) appear to act as functional antagonists in the regulation of fluid and electrolyte homeostasis and blood pressure. To further define the relations between these hormones in vivo, we investigated the effect of low doses of Ang II (1-10 ng/kg/min) on plasma ANF levels. We also evaluated the influence of ANF release on the renal and hormonal responses to Ang II. Studies were performed in anesthetized and conscious instrumented dogs during sustained saline load and converting enzyme inhibition. In the anesthetized dogs, Ang II significantly increased plasma ANF levels and ANF arteriovenous difference without changing either atrial pressures or hematocrit. In both conscious and anesthetized dogs, ANF increases were not correlated with blood pressure responses to Ang II and did not occur in control groups when Ang II was replaced by vehicle. Ang II-induced sodium retention and stimulation of aldosterone production were attenuated, and renin suppression was enhanced in dogs having the largest changes in plasma ANF in response to converting enzyme inhibition or Ang II. These results demonstrate that in volume-replete dogs Ang II can promote ANF release independently of changes in atrial pressures or systemic hemodynamics, suggesting that Ang II may exert a significantly modulatory effect on ANF secretion. The results also show significant relations between ANF and renal and adrenal responses to Ang II, which may suggest that, in turn, endogenous ANF modulates the effects of Ang II.",
keywords = "body fluid homeostasis, hemodynamics, kidney, renin-angiotensin-aldosterone system",
author = "M. Volpe and Atlas, {S. A.} and Sosa, {R. E.} and Marion, {D. E.} and Mueller, {F. B.} and Sealey, {J. E.} and Laragh, {J. H.}",
year = "1990",
language = "English",
volume = "67",
pages = "774--779",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses

AU - Volpe, M.

AU - Atlas, S. A.

AU - Sosa, R. E.

AU - Marion, D. E.

AU - Mueller, F. B.

AU - Sealey, J. E.

AU - Laragh, J. H.

PY - 1990

Y1 - 1990

N2 - Angiotensin II (Ang II) and atrial natriuretic factor (ANF) appear to act as functional antagonists in the regulation of fluid and electrolyte homeostasis and blood pressure. To further define the relations between these hormones in vivo, we investigated the effect of low doses of Ang II (1-10 ng/kg/min) on plasma ANF levels. We also evaluated the influence of ANF release on the renal and hormonal responses to Ang II. Studies were performed in anesthetized and conscious instrumented dogs during sustained saline load and converting enzyme inhibition. In the anesthetized dogs, Ang II significantly increased plasma ANF levels and ANF arteriovenous difference without changing either atrial pressures or hematocrit. In both conscious and anesthetized dogs, ANF increases were not correlated with blood pressure responses to Ang II and did not occur in control groups when Ang II was replaced by vehicle. Ang II-induced sodium retention and stimulation of aldosterone production were attenuated, and renin suppression was enhanced in dogs having the largest changes in plasma ANF in response to converting enzyme inhibition or Ang II. These results demonstrate that in volume-replete dogs Ang II can promote ANF release independently of changes in atrial pressures or systemic hemodynamics, suggesting that Ang II may exert a significantly modulatory effect on ANF secretion. The results also show significant relations between ANF and renal and adrenal responses to Ang II, which may suggest that, in turn, endogenous ANF modulates the effects of Ang II.

AB - Angiotensin II (Ang II) and atrial natriuretic factor (ANF) appear to act as functional antagonists in the regulation of fluid and electrolyte homeostasis and blood pressure. To further define the relations between these hormones in vivo, we investigated the effect of low doses of Ang II (1-10 ng/kg/min) on plasma ANF levels. We also evaluated the influence of ANF release on the renal and hormonal responses to Ang II. Studies were performed in anesthetized and conscious instrumented dogs during sustained saline load and converting enzyme inhibition. In the anesthetized dogs, Ang II significantly increased plasma ANF levels and ANF arteriovenous difference without changing either atrial pressures or hematocrit. In both conscious and anesthetized dogs, ANF increases were not correlated with blood pressure responses to Ang II and did not occur in control groups when Ang II was replaced by vehicle. Ang II-induced sodium retention and stimulation of aldosterone production were attenuated, and renin suppression was enhanced in dogs having the largest changes in plasma ANF in response to converting enzyme inhibition or Ang II. These results demonstrate that in volume-replete dogs Ang II can promote ANF release independently of changes in atrial pressures or systemic hemodynamics, suggesting that Ang II may exert a significantly modulatory effect on ANF secretion. The results also show significant relations between ANF and renal and adrenal responses to Ang II, which may suggest that, in turn, endogenous ANF modulates the effects of Ang II.

KW - body fluid homeostasis

KW - hemodynamics

KW - kidney

KW - renin-angiotensin-aldosterone system

UR - http://www.scopus.com/inward/record.url?scp=0025105751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025105751&partnerID=8YFLogxK

M3 - Article

C2 - 2144484

AN - SCOPUS:0025105751

VL - 67

SP - 774

EP - 779

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 3

ER -