TY - JOUR
T1 - Angiotensin-sympathetic system interactions in cardiovascular and metabolic disease
AU - Mancia, Giuseppe
AU - Dell'Oro, Raffaella
AU - Quarti-Trevano, Fosca
AU - Scopelliti, Francesco
AU - Grassi, Guido
PY - 2006/3
Y1 - 2006/3
N2 - BACKGROUND: Blood pressure, as well as blood volume homeostasis, depends to a large extent on humoral influences stemming from the renin-angiotensin axis and the sympathetic nervous system. Evidence has been provided that a large part of this homeostatic modulation is effected by the complex interactions between the two systems. OBJECTIVES: The present review will focus on three major issues. First it will examine the physiological and pathophysiological relevance of angiotensin-sympathetic crosstalk discussing possible sites, mechanisms and effects of the interaction. It will then address the clinical relevance of these inter-relationships by reviewing data collected in cardiovascular and non-cardiovascular diseases. Finally, the influences of angiotensin II on adrenergic function will be examined as possible targets of cardiovascular drug treatment. CONCLUSIONS: By interrupting the influences of angiotensin II on sympathetic function, therapeutic interventions aimed at blocking the renin-angiotensin system exert favourable effects on the haemodynamic, metabolic and renal profile. This has important implications for the treatment of hypertension, congestive heart failure, renal insufficiency and metabolic syndrome.
AB - BACKGROUND: Blood pressure, as well as blood volume homeostasis, depends to a large extent on humoral influences stemming from the renin-angiotensin axis and the sympathetic nervous system. Evidence has been provided that a large part of this homeostatic modulation is effected by the complex interactions between the two systems. OBJECTIVES: The present review will focus on three major issues. First it will examine the physiological and pathophysiological relevance of angiotensin-sympathetic crosstalk discussing possible sites, mechanisms and effects of the interaction. It will then address the clinical relevance of these inter-relationships by reviewing data collected in cardiovascular and non-cardiovascular diseases. Finally, the influences of angiotensin II on adrenergic function will be examined as possible targets of cardiovascular drug treatment. CONCLUSIONS: By interrupting the influences of angiotensin II on sympathetic function, therapeutic interventions aimed at blocking the renin-angiotensin system exert favourable effects on the haemodynamic, metabolic and renal profile. This has important implications for the treatment of hypertension, congestive heart failure, renal insufficiency and metabolic syndrome.
KW - Angiotensin II receptor blockers
KW - Heart failure
KW - Hypertension
KW - Insulin resistance
KW - Metabolic system
KW - Renin-angiotensin system
KW - Sympathetic nervous system
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U2 - 10.1097/01.hjh.0000220407.84363.fb
DO - 10.1097/01.hjh.0000220407.84363.fb
M3 - Article
C2 - 16601574
AN - SCOPUS:33745538005
VL - 24
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - SUPPL. 1
ER -