Anhedonia in depression symptomatology: Appetite dysregulation and defective brain reward processing

Research output: Contribution to journalReview article

Abstract

Anhedonia is an elusive symptom in depression symptomatology. The present review frames the notion of anhedonia as reduced ability to experience pleasure and diminished sensitivity to rewarding stimuli such as palatable food or social interaction within the context of appetite dysregulation in depression, addressing the main neural networks involved in the alteration of brain reward processing. This circuit-based framework focuses on selected brain regions such as lateral hypothalamus, ventral pallidum, lateral habenula and mesocorticolimbic target areas such as nucleus accumbens and ventral tegmental area. The examination in particular of the role of dopamine, orexin and GABAergic neurotransmission is complemented by the exploration of the endocannabinoid signaling as homeostatic, anti-stress system and its relevance in depression pathophysiology and anhedonia symptoms.

Original languageEnglish
Article number112041
JournalBehavioural Brain Research
Volume372
DOIs
Publication statusPublished - Oct 17 2019

Fingerprint

Anhedonia
Appetite
Reward
Depression
Brain
Food-Drug Interactions
Lateral Hypothalamic Area
Habenula
Endocannabinoids
Ventral Tegmental Area
Aptitude
Pleasure
Nucleus Accumbens
Interpersonal Relations
Synaptic Transmission
Dopamine

Keywords

  • Anhedonia
  • Depressive disorder
  • Endocannabinoid system
  • Lateral habenula
  • Lateral hypothalamus
  • Reward processing

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Anhedonia in depression symptomatology : Appetite dysregulation and defective brain reward processing. / Coccurello, Roberto.

In: Behavioural Brain Research, Vol. 372, 112041, 17.10.2019.

Research output: Contribution to journalReview article

@article{cf45ff54638848138741efe3f469862a,
title = "Anhedonia in depression symptomatology: Appetite dysregulation and defective brain reward processing",
abstract = "Anhedonia is an elusive symptom in depression symptomatology. The present review frames the notion of anhedonia as reduced ability to experience pleasure and diminished sensitivity to rewarding stimuli such as palatable food or social interaction within the context of appetite dysregulation in depression, addressing the main neural networks involved in the alteration of brain reward processing. This circuit-based framework focuses on selected brain regions such as lateral hypothalamus, ventral pallidum, lateral habenula and mesocorticolimbic target areas such as nucleus accumbens and ventral tegmental area. The examination in particular of the role of dopamine, orexin and GABAergic neurotransmission is complemented by the exploration of the endocannabinoid signaling as homeostatic, anti-stress system and its relevance in depression pathophysiology and anhedonia symptoms.",
keywords = "Anhedonia, Depressive disorder, Endocannabinoid system, Lateral habenula, Lateral hypothalamus, Reward processing",
author = "Roberto Coccurello",
year = "2019",
month = "10",
day = "17",
doi = "10.1016/j.bbr.2019.112041",
language = "English",
volume = "372",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

TY - JOUR

T1 - Anhedonia in depression symptomatology

T2 - Appetite dysregulation and defective brain reward processing

AU - Coccurello, Roberto

PY - 2019/10/17

Y1 - 2019/10/17

N2 - Anhedonia is an elusive symptom in depression symptomatology. The present review frames the notion of anhedonia as reduced ability to experience pleasure and diminished sensitivity to rewarding stimuli such as palatable food or social interaction within the context of appetite dysregulation in depression, addressing the main neural networks involved in the alteration of brain reward processing. This circuit-based framework focuses on selected brain regions such as lateral hypothalamus, ventral pallidum, lateral habenula and mesocorticolimbic target areas such as nucleus accumbens and ventral tegmental area. The examination in particular of the role of dopamine, orexin and GABAergic neurotransmission is complemented by the exploration of the endocannabinoid signaling as homeostatic, anti-stress system and its relevance in depression pathophysiology and anhedonia symptoms.

AB - Anhedonia is an elusive symptom in depression symptomatology. The present review frames the notion of anhedonia as reduced ability to experience pleasure and diminished sensitivity to rewarding stimuli such as palatable food or social interaction within the context of appetite dysregulation in depression, addressing the main neural networks involved in the alteration of brain reward processing. This circuit-based framework focuses on selected brain regions such as lateral hypothalamus, ventral pallidum, lateral habenula and mesocorticolimbic target areas such as nucleus accumbens and ventral tegmental area. The examination in particular of the role of dopamine, orexin and GABAergic neurotransmission is complemented by the exploration of the endocannabinoid signaling as homeostatic, anti-stress system and its relevance in depression pathophysiology and anhedonia symptoms.

KW - Anhedonia

KW - Depressive disorder

KW - Endocannabinoid system

KW - Lateral habenula

KW - Lateral hypothalamus

KW - Reward processing

UR - http://www.scopus.com/inward/record.url?scp=85067878742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067878742&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2019.112041

DO - 10.1016/j.bbr.2019.112041

M3 - Review article

AN - SCOPUS:85067878742

VL - 372

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

M1 - 112041

ER -