Anidulafungin in combination with amphotericin B against Aspergillus fumigatus

Elisabetta Spreghini, Fiorenza Orlando, Alfredo Santinelli, Eleonora Pisa, Cristian Loretelli, Esther Manso, Maria Eleonara Milici, Giorgio Scalise, Francesco Barchiesi

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.

Original languageEnglish
Pages (from-to)4035-4039
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number9
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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