TY - JOUR
T1 - Anidulafungin in combination with amphotericin B against Aspergillus fumigatus
AU - Spreghini, Elisabetta
AU - Orlando, Fiorenza
AU - Santinelli, Alfredo
AU - Pisa, Eleonora
AU - Loretelli, Cristian
AU - Manso, Esther
AU - Milici, Maria Eleonara
AU - Scalise, Giorgio
AU - Barchiesi, Francesco
PY - 2009
Y1 - 2009
N2 - We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.
AB - We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.
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U2 - 10.1128/AAC.00659-09
DO - 10.1128/AAC.00659-09
M3 - Article
C2 - 19596890
AN - SCOPUS:70349100799
VL - 53
SP - 4035
EP - 4039
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 9
ER -