Animal model for investigation of fluphenazine kinetics after administration of long-acting esters

A. C. Altamura; R. Whelpton; S. H. Curry

Animal model for investigation of fluphenazine kinetics after administration of long-acting esters

A. C. Altamura, R. Whelpton, S. H. Curry

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

A model was developed for studying fluphenazine availability and disposition. Rats were given doses of radioactively labelled esters of fluphenazine by intramuscular injection. Radioactivity excreted in urine, faeces, and expired air was assessed for fluphenazine esters, fluphenazine, and CO₂ content. Levels of fluphenazine and its esters were measured in plasma, brain, and muscle (injected and non-injected samples). The data mimicked those obtained in other studies involving the same material given to human subjects, and posed new questions concerning the factors controlling fluphenazine availability when given as 'long-acting' intramuscular injections.

Original language	English
Pages (from-to)	65-72
Number of pages	8
Journal	Biopharmaceutics and Drug Disposition
Volume	1
Issue number	2
Publication status	Published - 1979

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "A model was developed for studying fluphenazine availability and disposition. Rats were given doses of radioactively labelled esters of fluphenazine by intramuscular injection. Radioactivity excreted in urine, faeces, and expired air was assessed for fluphenazine esters, fluphenazine, and CO2 content. Levels of fluphenazine and its esters were measured in plasma, brain, and muscle (injected and non-injected samples). The data mimicked those obtained in other studies involving the same material given to human subjects, and posed new questions concerning the factors controlling fluphenazine availability when given as 'long-acting' intramuscular injections.",

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AU - Altamura, A. C.

AU - Whelpton, R.

AU - Curry, S. H.

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N2 - A model was developed for studying fluphenazine availability and disposition. Rats were given doses of radioactively labelled esters of fluphenazine by intramuscular injection. Radioactivity excreted in urine, faeces, and expired air was assessed for fluphenazine esters, fluphenazine, and CO2 content. Levels of fluphenazine and its esters were measured in plasma, brain, and muscle (injected and non-injected samples). The data mimicked those obtained in other studies involving the same material given to human subjects, and posed new questions concerning the factors controlling fluphenazine availability when given as 'long-acting' intramuscular injections.

AB - A model was developed for studying fluphenazine availability and disposition. Rats were given doses of radioactively labelled esters of fluphenazine by intramuscular injection. Radioactivity excreted in urine, faeces, and expired air was assessed for fluphenazine esters, fluphenazine, and CO2 content. Levels of fluphenazine and its esters were measured in plasma, brain, and muscle (injected and non-injected samples). The data mimicked those obtained in other studies involving the same material given to human subjects, and posed new questions concerning the factors controlling fluphenazine availability when given as 'long-acting' intramuscular injections.

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Animal model for investigation of fluphenazine kinetics after administration of long-acting esters

Abstract

ASJC Scopus subject areas

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