Animal models for meniscus repair and regeneration

Daniela Deponti, Alessia Di Giancamillo, Celeste Scotti, Giuseppe M. Peretti, Ivan Martin

Research output: Contribution to journalArticlepeer-review

Abstract

The meniscus plays an important role in knee function and mechanics. Meniscal lesions, however, are common phenomena and this tissue is not able to achieve spontaneous successful repair, particularly in the inner avascular zone. Several animal models have been studied and proposed for testing different reparative approaches, as well as for studying regenerative methods aiming to restore the original shape and function of this structure. This review summarizes the gross anatomy, function, ultrastructure and biochemical composition of the knee meniscus in several animal models in comparison with the human meniscus. The relevance of the models is discussed from the point of view of basic research as well as of clinical translation for meniscal repair, substitution and regeneration. Finally, the advantages and disadvantages of each model for various research directions are critically discussed.

Original languageEnglish
Pages (from-to)512-527
Number of pages16
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume9
Issue number5
DOIs
Publication statusPublished - May 1 2015

Keywords

  • Animal model
  • Biomaterials
  • Meniscus
  • Regenerative medicine
  • Scaffold
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Medicine(all)

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