Animal models for the study of cancer-induced anorexia

S. Garattini, A. Guaitani

Research output: Contribution to journalArticle

Abstract

Walker carcinoma 256/B transplanted sc in CD-COBS rats induce a decrease of food intake when the tumor size is less than 5% of the body weight. This anorexia is accompanied by a decrease of the adipose tissue and, to a lesser extent, of muscular tissue. The mechanism involved in cancer-induced anorexia seems to be different from that of classic centrally acting anorectic agents. Among the drugs tested to counteract this anorexia only cyproheptadine shows a modest effect. Cyclophosphamide reduces tumor growth and prevents decrease in food intake. It is suggested that Walker carcinoma 256/B may be a useful animal model to study problems related to cancer-induced anorexia and cachexia.

Original languageEnglish
Pages (from-to)23-35
Number of pages13
JournalCancer Treatment Reports
Volume65
Issue numberSuppl. 5
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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