Animal models in studies of cardiotoxicity side effects from antiblastic drugs in patients and occupational exposed workers

Monica Lamberti, Giancarlo Giovane, Elpidio M. Garzillo, Franca Avino, Antonia Feola, Stefania Porto, Vincenzo Tombolini, Marina Di Domenico

Research output: Contribution to journalArticle

Abstract

Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.

Original languageEnglish
Article number240642
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Drug-Related Side Effects and Adverse Reactions
Animals
Animal Models
cyclopentenyl cytosine
Pharmaceutical Preparations
Oxidative stress
Free Radicals
Oxidative Stress
Apoptosis
Morbidity
Cardiotoxicity
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Animal models in studies of cardiotoxicity side effects from antiblastic drugs in patients and occupational exposed workers. / Lamberti, Monica; Giovane, Giancarlo; Garzillo, Elpidio M.; Avino, Franca; Feola, Antonia; Porto, Stefania; Tombolini, Vincenzo; Di Domenico, Marina.

In: BioMed Research International, Vol. 2014, 240642, 2014.

Research output: Contribution to journalArticle

Lamberti, Monica ; Giovane, Giancarlo ; Garzillo, Elpidio M. ; Avino, Franca ; Feola, Antonia ; Porto, Stefania ; Tombolini, Vincenzo ; Di Domenico, Marina. / Animal models in studies of cardiotoxicity side effects from antiblastic drugs in patients and occupational exposed workers. In: BioMed Research International. 2014 ; Vol. 2014.
@article{2e0a36970f99417ab495a33b272a1f39,
title = "Animal models in studies of cardiotoxicity side effects from antiblastic drugs in patients and occupational exposed workers",
abstract = "Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.",
author = "Monica Lamberti and Giancarlo Giovane and Garzillo, {Elpidio M.} and Franca Avino and Antonia Feola and Stefania Porto and Vincenzo Tombolini and {Di Domenico}, Marina",
year = "2014",
doi = "10.1155/2014/240642",
language = "English",
volume = "2014",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Animal models in studies of cardiotoxicity side effects from antiblastic drugs in patients and occupational exposed workers

AU - Lamberti, Monica

AU - Giovane, Giancarlo

AU - Garzillo, Elpidio M.

AU - Avino, Franca

AU - Feola, Antonia

AU - Porto, Stefania

AU - Tombolini, Vincenzo

AU - Di Domenico, Marina

PY - 2014

Y1 - 2014

N2 - Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.

AB - Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.

UR - http://www.scopus.com/inward/record.url?scp=84896114608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896114608&partnerID=8YFLogxK

U2 - 10.1155/2014/240642

DO - 10.1155/2014/240642

M3 - Article

C2 - 24701565

AN - SCOPUS:84896114608

VL - 2014

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 240642

ER -