Animal models of hypertension

An overview

Lilach O. Lerman, Alejandro R. Chade, Vincenzo Sica, Claudio Napoli

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Hypertension is a multifactorial disease involving complex interactions between genetic and environmental factors. Development of experimental models of hypertension allowed dissection and isolation of various factors associated with regulation of blood pressure, inheritance of hypertensive traits, and cellular responses to injury. The phenotype-driven approach is taking advantage of selective breeding of animals (primarily rats) that exhibit a desired phenotype, like the useful SHR. Genotype-driven models include transgenic techniques, in which mice are the most successful for selective deletion or overexpression of target genes. Notably, a combination of comparative genomics strategies and phenotypic correlates enhances the utility of hypertension models and their clinical relevance. Indeed, experimental models enabled development of targeted interventions aimed at decreasing not only blood pressure but also target organ injury. Continued utilization of experimental models simulating human hypertension, particularly those that combine other clinically relevant comorbidities like obesity or hypercholesterolemia, may afford development of effective strategies to address this common disease. Nevertheless, a cautious approach is mandatory when experimental findings in these models are extrapolated to human hypertension.

Original languageEnglish
Pages (from-to)160-173
Number of pages14
JournalThe Journal of Laboratory and Clinical Medicine
Volume146
Issue number3
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Animal Models
Hypertension
Theoretical Models
Blood Pressure
Phenotype
Wounds and Injuries
Genomics
Hypercholesterolemia
Dissection
Comorbidity
Obesity
Genotype
Genes

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Animal models of hypertension : An overview. / Lerman, Lilach O.; Chade, Alejandro R.; Sica, Vincenzo; Napoli, Claudio.

In: The Journal of Laboratory and Clinical Medicine, Vol. 146, No. 3, 09.2005, p. 160-173.

Research output: Contribution to journalArticle

Lerman, Lilach O. ; Chade, Alejandro R. ; Sica, Vincenzo ; Napoli, Claudio. / Animal models of hypertension : An overview. In: The Journal of Laboratory and Clinical Medicine. 2005 ; Vol. 146, No. 3. pp. 160-173.
@article{a13414a241ff46b990148216a01fd8f1,
title = "Animal models of hypertension: An overview",
abstract = "Hypertension is a multifactorial disease involving complex interactions between genetic and environmental factors. Development of experimental models of hypertension allowed dissection and isolation of various factors associated with regulation of blood pressure, inheritance of hypertensive traits, and cellular responses to injury. The phenotype-driven approach is taking advantage of selective breeding of animals (primarily rats) that exhibit a desired phenotype, like the useful SHR. Genotype-driven models include transgenic techniques, in which mice are the most successful for selective deletion or overexpression of target genes. Notably, a combination of comparative genomics strategies and phenotypic correlates enhances the utility of hypertension models and their clinical relevance. Indeed, experimental models enabled development of targeted interventions aimed at decreasing not only blood pressure but also target organ injury. Continued utilization of experimental models simulating human hypertension, particularly those that combine other clinically relevant comorbidities like obesity or hypercholesterolemia, may afford development of effective strategies to address this common disease. Nevertheless, a cautious approach is mandatory when experimental findings in these models are extrapolated to human hypertension.",
author = "Lerman, {Lilach O.} and Chade, {Alejandro R.} and Vincenzo Sica and Claudio Napoli",
year = "2005",
month = "9",
doi = "10.1016/j.lab.2005.05.005",
language = "English",
volume = "146",
pages = "160--173",
journal = "Journal of Laboratory and Clinical Medicine",
issn = "0022-2143",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Animal models of hypertension

T2 - An overview

AU - Lerman, Lilach O.

AU - Chade, Alejandro R.

AU - Sica, Vincenzo

AU - Napoli, Claudio

PY - 2005/9

Y1 - 2005/9

N2 - Hypertension is a multifactorial disease involving complex interactions between genetic and environmental factors. Development of experimental models of hypertension allowed dissection and isolation of various factors associated with regulation of blood pressure, inheritance of hypertensive traits, and cellular responses to injury. The phenotype-driven approach is taking advantage of selective breeding of animals (primarily rats) that exhibit a desired phenotype, like the useful SHR. Genotype-driven models include transgenic techniques, in which mice are the most successful for selective deletion or overexpression of target genes. Notably, a combination of comparative genomics strategies and phenotypic correlates enhances the utility of hypertension models and their clinical relevance. Indeed, experimental models enabled development of targeted interventions aimed at decreasing not only blood pressure but also target organ injury. Continued utilization of experimental models simulating human hypertension, particularly those that combine other clinically relevant comorbidities like obesity or hypercholesterolemia, may afford development of effective strategies to address this common disease. Nevertheless, a cautious approach is mandatory when experimental findings in these models are extrapolated to human hypertension.

AB - Hypertension is a multifactorial disease involving complex interactions between genetic and environmental factors. Development of experimental models of hypertension allowed dissection and isolation of various factors associated with regulation of blood pressure, inheritance of hypertensive traits, and cellular responses to injury. The phenotype-driven approach is taking advantage of selective breeding of animals (primarily rats) that exhibit a desired phenotype, like the useful SHR. Genotype-driven models include transgenic techniques, in which mice are the most successful for selective deletion or overexpression of target genes. Notably, a combination of comparative genomics strategies and phenotypic correlates enhances the utility of hypertension models and their clinical relevance. Indeed, experimental models enabled development of targeted interventions aimed at decreasing not only blood pressure but also target organ injury. Continued utilization of experimental models simulating human hypertension, particularly those that combine other clinically relevant comorbidities like obesity or hypercholesterolemia, may afford development of effective strategies to address this common disease. Nevertheless, a cautious approach is mandatory when experimental findings in these models are extrapolated to human hypertension.

UR - http://www.scopus.com/inward/record.url?scp=23944435164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944435164&partnerID=8YFLogxK

U2 - 10.1016/j.lab.2005.05.005

DO - 10.1016/j.lab.2005.05.005

M3 - Article

VL - 146

SP - 160

EP - 173

JO - Journal of Laboratory and Clinical Medicine

JF - Journal of Laboratory and Clinical Medicine

SN - 0022-2143

IS - 3

ER -