TY - JOUR
T1 - Animal models of migraine
T2 - Looking at the component parts of a complex disorder
AU - Bergerot, A.
AU - Holland, P. R.
AU - Akerman, S.
AU - Bartsch, T.
AU - Ahn, A. H.
AU - MaassenVanDenBrink, A.
AU - Reuter, U.
AU - Tassorelli, C.
AU - Schoenen, J.
AU - Mitsikostas, D. D.
AU - Van Den Maagdenberg, A. M J M
AU - Goadsby, P. J.
PY - 2006/9
Y1 - 2006/9
N2 - Animal models of human disease have been extremely helpful both in advancing the understanding of brain disorders and in developing new therapeutic approaches. Models for studying headache mechanisms, particularly those directed at migraine, have been developed and exploited efficiently in the last decade, leading to better understanding of the potential mechanisms of the disorder and of the action for antimigraine treatments. Model systems employed have focused on the pain-producing cranial structures, the large vessels and dura mater, in order to provide reproducible physiological measures that could be subject to pharmacological exploration. A wide range of methods using both in vivo and in vitro approaches are now employed; these range from manipulation of the mouse genome in order to produce animals with human disease-producing mutations, through sensitive immunohistochemical methods to vascular, neurovascular and electrophysiological studies. No one model system in experimental animals can explain all the features of migraine; however, the systems available have begun to offer ways to dissect migraine's component parts to allow a better understanding of the problem and the development of new treatment strategies.
AB - Animal models of human disease have been extremely helpful both in advancing the understanding of brain disorders and in developing new therapeutic approaches. Models for studying headache mechanisms, particularly those directed at migraine, have been developed and exploited efficiently in the last decade, leading to better understanding of the potential mechanisms of the disorder and of the action for antimigraine treatments. Model systems employed have focused on the pain-producing cranial structures, the large vessels and dura mater, in order to provide reproducible physiological measures that could be subject to pharmacological exploration. A wide range of methods using both in vivo and in vitro approaches are now employed; these range from manipulation of the mouse genome in order to produce animals with human disease-producing mutations, through sensitive immunohistochemical methods to vascular, neurovascular and electrophysiological studies. No one model system in experimental animals can explain all the features of migraine; however, the systems available have begun to offer ways to dissect migraine's component parts to allow a better understanding of the problem and the development of new treatment strategies.
KW - Animal models of migraine
KW - Trigeminovascular-mediated nociception
UR - http://www.scopus.com/inward/record.url?scp=33748641238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748641238&partnerID=8YFLogxK
U2 - 10.1111/j.1460-9568.2006.05036.x
DO - 10.1111/j.1460-9568.2006.05036.x
M3 - Article
C2 - 17004916
AN - SCOPUS:33748641238
VL - 24
SP - 1517
EP - 1534
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 6
ER -