Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

Maria Vetro, Barbara Costa, Giulia Donvito, Noemi Arrighetti, Laura Cipolla, Paola Perego, Federica Compostella, Fiamma Ronchetti, Diego Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

New glucuronosyldiacylglycerol (GlcADG) analogues based on a 2-O-β-d-glucopyranosyl-sn-glycerol scaffold and carrying one or two acyl chains of different lengths have been synthesized as phosphatidylinositol 3-phosphate (PI3P) mimics targeting the protein kinase Akt. The Akt inhibitory effect of the prepared compounds was assayed using an in vitro kinase assay. The antiproliferative activity of the compounds was tested in the human ovarian carcinoma IGROV-1 cell line in which we found that two of them could inhibit proliferation, in keeping with the target inhibitory effect.

Original languageEnglish
Pages (from-to)1091-1099
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number4
DOIs
Publication statusPublished - Jan 28 2015

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry
  • Medicine(all)

Fingerprint Dive into the research topics of 'Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt'. Together they form a unique fingerprint.

Cite this