Anionic phospholipids calcium binding sites in Duchenne and murine x- linked muscular dystrophy

M. Moggio, A. Prelle, G. Fagiolari, N. Checcarelli, M. Sciacco, P. Ciscato, G. Scarlato

Research output: Contribution to journalArticlepeer-review


Duchenne muscular dystrophy (DMD) and murine X-linked muscular dystrophy (mdx) are genetically homologous and both characterized by absence of dystrophin. The function of this protein is not defined nor is the pathogenesis of the severe muscle necrosis and progressive weakness found in DMD but not in mdx. Recently we found that anionic phospholipid (AP) calcium binding sites are lacking at the muscle cell surface in DMD and we correlated these data with dystrophin deficiency and muscle necrosis. In order to verify the role of AP lack in the pathogenesis of muscle necrosis in DMD we studied the ultrastructural localization of these Ca++ receptors in mdx muscle membrane showing that they are normally represented as they are in control mouse and normal human muscle. The absence of AP in DMD compared with a normal distribution in mdx suggests that these calcium binding site alterations play an important and specific role in muscle fiber necrosis.

Original languageEnglish
Pages (from-to)485-488
Number of pages4
JournalMuscle and Nerve
Issue number5
Publication statusPublished - 1994


  • calcium binding sites
  • Duchenne muscular dystrophy
  • mdx

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'Anionic phospholipids calcium binding sites in Duchenne and murine x- linked muscular dystrophy'. Together they form a unique fingerprint.

Cite this