Abstract
The relationship between the spatial location of limb and the activity of cerebellar neurons has received little attention and its nature still remains ambiguous. To address this question we studied the activity of Purkinje and nucleus interpositus cells in relation to the spatial location of rat forelimb. A computer-controlled robot arm displaced the limb passively across 15 positions distributed on a parasagittal plane. The limb was upheld for 8 s in each position, which was identified by the Cartesian coordinates of the forepaw. We selected the neurons whose activities were significantly modulated by forepaw position and found that the majority represented preferentially one spatial dimension of the Cartesian plane both in the cerebellar cortex and nucleus interpositus. In particular, the antero-posterior axis was best represented in cerebellar neuronal discharges. This result suggests that the intermediate part of the cerebellum might encode limb position by way of an anisotropic representation of the spatial coordinates of the limb end-point.
| Original language | English |
|---|---|
| Pages (from-to) | 127-136 |
| Number of pages | 10 |
| Journal | Brain Research |
| Volume | 972 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - May 16 2003 |
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Keywords
- Electrophysiology
- Forelimb position
- Intermediate cerebellum
- Proprioception
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Anisotropic representation of forelimb position in the cerebellar cortex and nucleus interpositus of the rat. / Casabona, Antonino; Valle, Maria Stella; Bosco, Gianfranco; Garifoli, Angelo; Lombardo, Salvatore A.; Perciavalle, Vincenzo.
In: Brain Research, Vol. 972, No. 1-2, 16.05.2003, p. 127-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anisotropic representation of forelimb position in the cerebellar cortex and nucleus interpositus of the rat
AU - Casabona, Antonino
AU - Valle, Maria Stella
AU - Bosco, Gianfranco
AU - Garifoli, Angelo
AU - Lombardo, Salvatore A.
AU - Perciavalle, Vincenzo
PY - 2003/5/16
Y1 - 2003/5/16
N2 - The relationship between the spatial location of limb and the activity of cerebellar neurons has received little attention and its nature still remains ambiguous. To address this question we studied the activity of Purkinje and nucleus interpositus cells in relation to the spatial location of rat forelimb. A computer-controlled robot arm displaced the limb passively across 15 positions distributed on a parasagittal plane. The limb was upheld for 8 s in each position, which was identified by the Cartesian coordinates of the forepaw. We selected the neurons whose activities were significantly modulated by forepaw position and found that the majority represented preferentially one spatial dimension of the Cartesian plane both in the cerebellar cortex and nucleus interpositus. In particular, the antero-posterior axis was best represented in cerebellar neuronal discharges. This result suggests that the intermediate part of the cerebellum might encode limb position by way of an anisotropic representation of the spatial coordinates of the limb end-point.
AB - The relationship between the spatial location of limb and the activity of cerebellar neurons has received little attention and its nature still remains ambiguous. To address this question we studied the activity of Purkinje and nucleus interpositus cells in relation to the spatial location of rat forelimb. A computer-controlled robot arm displaced the limb passively across 15 positions distributed on a parasagittal plane. The limb was upheld for 8 s in each position, which was identified by the Cartesian coordinates of the forepaw. We selected the neurons whose activities were significantly modulated by forepaw position and found that the majority represented preferentially one spatial dimension of the Cartesian plane both in the cerebellar cortex and nucleus interpositus. In particular, the antero-posterior axis was best represented in cerebellar neuronal discharges. This result suggests that the intermediate part of the cerebellum might encode limb position by way of an anisotropic representation of the spatial coordinates of the limb end-point.
KW - Electrophysiology
KW - Forelimb position
KW - Intermediate cerebellum
KW - Proprioception
UR - http://www.scopus.com/inward/record.url?scp=0037449204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037449204&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(03)02513-7
DO - 10.1016/S0006-8993(03)02513-7
M3 - Article
C2 - 12711085
AN - SCOPUS:0037449204
VL - 972
SP - 127
EP - 136
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -