ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome

Leonardo De Luca, Leonardo Bolognese, Marco Valgimigli, Roberto Ceravolo, Gian Battista Danzi, Emanuela Piccaluga, Serena Rakar, Alberto Cremonesi, Francesco Maria Bovenzi, R. Abbate, F. Andreotti, L. Bolognese, G. Biondi-Zoccai, F. M. Bovenz, D. Capodanno, R. Caporale, P. Capranzano, N. Carrabba, G. Casella, C. CavalliniR. Ceravolo, P. Colombo, M. R. Conte, S. Cordone, A. Cremonesi, G. B. Danzi, M. Del Pinto, G. De Luca, L. De Luca, S. De Servi, E. Di Lorenzo, G. Di Pasquale, G. Esposito, R. Farina, A. Fiscella, D. Formigli, S. Galli, P. Giudice, G. Gonzi, C. Greco, N. B. Grieco, L. La Vecchia, M. Lazzari, C. Lettieri, M. Lettino, U. Limbruno, A. Lupi, A. Macchi, M. Marini, M. Marzilli, A. Montinaro, G. Musumeci, A. Navazio, Z. Olivari, L. Oltrona Visconti, J. A. Oreglia, F. Ottani, G. Parodi, G. Pasquetto, G. Patti, A. Perkan, G. P. Perna, E. Piccaluga, F. Piscione, F. Prati, S. Rakar, R. Ravasio, F. Ronco, R. Rossini, A. Rubboli, F. Saia, G. Sardella, G. Satullo, S. Savonitto, P. Sbarzaglia, G. Scorcu, N. Signore, G. Tarantini, P. Terrosu, L. Testa, M. Tubaro, S. Valente, M. Valgimigli, F. Varbella, M. Vatrano

Research output: Contribution to journalArticle

Abstract

Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y12 receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.

Original languageEnglish
Pages (from-to)C2-C28
JournalEuropean Heart Journal, Supplement
Volume16
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Acute Coronary Syndrome
Purinergic P2Y Receptor Antagonists
clopidogrel
Platelet Aggregation Inhibitors
Therapeutics
Research
Pharmaceutical Preparations
Uncertainty
Blood Platelets
Randomized Controlled Trials

Keywords

  • Acute coronary syndrome
  • Antiplatelet agents
  • Aspirin
  • Cangrelor
  • Clopidogrel
  • Prasugrel
  • Ticagrelor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

De Luca, L., Bolognese, L., Valgimigli, M., Ceravolo, R., Danzi, G. B., Piccaluga, E., ... Vatrano, M. (2014). ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome. European Heart Journal, Supplement, 16, C2-C28. https://doi.org/10.1093/eurheartj/suu030

ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome. / De Luca, Leonardo; Bolognese, Leonardo; Valgimigli, Marco; Ceravolo, Roberto; Danzi, Gian Battista; Piccaluga, Emanuela; Rakar, Serena; Cremonesi, Alberto; Bovenzi, Francesco Maria; Abbate, R.; Andreotti, F.; Bolognese, L.; Biondi-Zoccai, G.; Bovenz, F. M.; Capodanno, D.; Caporale, R.; Capranzano, P.; Carrabba, N.; Casella, G.; Cavallini, C.; Ceravolo, R.; Colombo, P.; Conte, M. R.; Cordone, S.; Cremonesi, A.; Danzi, G. B.; Del Pinto, M.; De Luca, G.; De Luca, L.; De Servi, S.; Di Lorenzo, E.; Di Pasquale, G.; Esposito, G.; Farina, R.; Fiscella, A.; Formigli, D.; Galli, S.; Giudice, P.; Gonzi, G.; Greco, C.; Grieco, N. B.; La Vecchia, L.; Lazzari, M.; Lettieri, C.; Lettino, M.; Limbruno, U.; Lupi, A.; Macchi, A.; Marini, M.; Marzilli, M.; Montinaro, A.; Musumeci, G.; Navazio, A.; Olivari, Z.; Oltrona Visconti, L.; Oreglia, J. A.; Ottani, F.; Parodi, G.; Pasquetto, G.; Patti, G.; Perkan, A.; Perna, G. P.; Piccaluga, E.; Piscione, F.; Prati, F.; Rakar, S.; Ravasio, R.; Ronco, F.; Rossini, R.; Rubboli, A.; Saia, F.; Sardella, G.; Satullo, G.; Savonitto, S.; Sbarzaglia, P.; Scorcu, G.; Signore, N.; Tarantini, G.; Terrosu, P.; Testa, L.; Tubaro, M.; Valente, S.; Valgimigli, M.; Varbella, F.; Vatrano, M.

In: European Heart Journal, Supplement, Vol. 16, 01.12.2014, p. C2-C28.

Research output: Contribution to journalArticle

De Luca, L, Bolognese, L, Valgimigli, M, Ceravolo, R, Danzi, GB, Piccaluga, E, Rakar, S, Cremonesi, A, Bovenzi, FM, Abbate, R, Andreotti, F, Bolognese, L, Biondi-Zoccai, G, Bovenz, FM, Capodanno, D, Caporale, R, Capranzano, P, Carrabba, N, Casella, G, Cavallini, C, Ceravolo, R, Colombo, P, Conte, MR, Cordone, S, Cremonesi, A, Danzi, GB, Del Pinto, M, De Luca, G, De Luca, L, De Servi, S, Di Lorenzo, E, Di Pasquale, G, Esposito, G, Farina, R, Fiscella, A, Formigli, D, Galli, S, Giudice, P, Gonzi, G, Greco, C, Grieco, NB, La Vecchia, L, Lazzari, M, Lettieri, C, Lettino, M, Limbruno, U, Lupi, A, Macchi, A, Marini, M, Marzilli, M, Montinaro, A, Musumeci, G, Navazio, A, Olivari, Z, Oltrona Visconti, L, Oreglia, JA, Ottani, F, Parodi, G, Pasquetto, G, Patti, G, Perkan, A, Perna, GP, Piccaluga, E, Piscione, F, Prati, F, Rakar, S, Ravasio, R, Ronco, F, Rossini, R, Rubboli, A, Saia, F, Sardella, G, Satullo, G, Savonitto, S, Sbarzaglia, P, Scorcu, G, Signore, N, Tarantini, G, Terrosu, P, Testa, L, Tubaro, M, Valente, S, Valgimigli, M, Varbella, F & Vatrano, M 2014, 'ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome', European Heart Journal, Supplement, vol. 16, pp. C2-C28. https://doi.org/10.1093/eurheartj/suu030
De Luca L, Bolognese L, Valgimigli M, Ceravolo R, Danzi GB, Piccaluga E et al. ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome. European Heart Journal, Supplement. 2014 Dec 1;16:C2-C28. https://doi.org/10.1093/eurheartj/suu030
De Luca, Leonardo ; Bolognese, Leonardo ; Valgimigli, Marco ; Ceravolo, Roberto ; Danzi, Gian Battista ; Piccaluga, Emanuela ; Rakar, Serena ; Cremonesi, Alberto ; Bovenzi, Francesco Maria ; Abbate, R. ; Andreotti, F. ; Bolognese, L. ; Biondi-Zoccai, G. ; Bovenz, F. M. ; Capodanno, D. ; Caporale, R. ; Capranzano, P. ; Carrabba, N. ; Casella, G. ; Cavallini, C. ; Ceravolo, R. ; Colombo, P. ; Conte, M. R. ; Cordone, S. ; Cremonesi, A. ; Danzi, G. B. ; Del Pinto, M. ; De Luca, G. ; De Luca, L. ; De Servi, S. ; Di Lorenzo, E. ; Di Pasquale, G. ; Esposito, G. ; Farina, R. ; Fiscella, A. ; Formigli, D. ; Galli, S. ; Giudice, P. ; Gonzi, G. ; Greco, C. ; Grieco, N. B. ; La Vecchia, L. ; Lazzari, M. ; Lettieri, C. ; Lettino, M. ; Limbruno, U. ; Lupi, A. ; Macchi, A. ; Marini, M. ; Marzilli, M. ; Montinaro, A. ; Musumeci, G. ; Navazio, A. ; Olivari, Z. ; Oltrona Visconti, L. ; Oreglia, J. A. ; Ottani, F. ; Parodi, G. ; Pasquetto, G. ; Patti, G. ; Perkan, A. ; Perna, G. P. ; Piccaluga, E. ; Piscione, F. ; Prati, F. ; Rakar, S. ; Ravasio, R. ; Ronco, F. ; Rossini, R. ; Rubboli, A. ; Saia, F. ; Sardella, G. ; Satullo, G. ; Savonitto, S. ; Sbarzaglia, P. ; Scorcu, G. ; Signore, N. ; Tarantini, G. ; Terrosu, P. ; Testa, L. ; Tubaro, M. ; Valente, S. ; Valgimigli, M. ; Varbella, F. ; Vatrano, M. / ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome. In: European Heart Journal, Supplement. 2014 ; Vol. 16. pp. C2-C28.
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T1 - ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome

AU - De Luca, Leonardo

AU - Bolognese, Leonardo

AU - Valgimigli, Marco

AU - Ceravolo, Roberto

AU - Danzi, Gian Battista

AU - Piccaluga, Emanuela

AU - Rakar, Serena

AU - Cremonesi, Alberto

AU - Bovenzi, Francesco Maria

AU - Abbate, R.

AU - Andreotti, F.

AU - Bolognese, L.

AU - Biondi-Zoccai, G.

AU - Bovenz, F. M.

AU - Capodanno, D.

AU - Caporale, R.

AU - Capranzano, P.

AU - Carrabba, N.

AU - Casella, G.

AU - Cavallini, C.

AU - Ceravolo, R.

AU - Colombo, P.

AU - Conte, M. R.

AU - Cordone, S.

AU - Cremonesi, A.

AU - Danzi, G. B.

AU - Del Pinto, M.

AU - De Luca, G.

AU - De Luca, L.

AU - De Servi, S.

AU - Di Lorenzo, E.

AU - Di Pasquale, G.

AU - Esposito, G.

AU - Farina, R.

AU - Fiscella, A.

AU - Formigli, D.

AU - Galli, S.

AU - Giudice, P.

AU - Gonzi, G.

AU - Greco, C.

AU - Grieco, N. B.

AU - La Vecchia, L.

AU - Lazzari, M.

AU - Lettieri, C.

AU - Lettino, M.

AU - Limbruno, U.

AU - Lupi, A.

AU - Macchi, A.

AU - Marini, M.

AU - Marzilli, M.

AU - Montinaro, A.

AU - Musumeci, G.

AU - Navazio, A.

AU - Olivari, Z.

AU - Oltrona Visconti, L.

AU - Oreglia, J. A.

AU - Ottani, F.

AU - Parodi, G.

AU - Pasquetto, G.

AU - Patti, G.

AU - Perkan, A.

AU - Perna, G. P.

AU - Piccaluga, E.

AU - Piscione, F.

AU - Prati, F.

AU - Rakar, S.

AU - Ravasio, R.

AU - Ronco, F.

AU - Rossini, R.

AU - Rubboli, A.

AU - Saia, F.

AU - Sardella, G.

AU - Satullo, G.

AU - Savonitto, S.

AU - Sbarzaglia, P.

AU - Scorcu, G.

AU - Signore, N.

AU - Tarantini, G.

AU - Terrosu, P.

AU - Testa, L.

AU - Tubaro, M.

AU - Valente, S.

AU - Valgimigli, M.

AU - Varbella, F.

AU - Vatrano, M.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y12 receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.

AB - Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y12 receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.

KW - Acute coronary syndrome

KW - Antiplatelet agents

KW - Aspirin

KW - Cangrelor

KW - Clopidogrel

KW - Prasugrel

KW - Ticagrelor

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