Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer

Sofia Avnet, Nicola Baldini, Lucie Brisson, Stine Falsig Pedersen, Paolo E Porporato, Pierre Sonveaux, Gyorgy Szabadkai, Silvia Pastorekova

Research output: Contribution to journalReview article

Abstract

The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of metabolic enzymes and their upstream regulators and abnormal fluxes of metabolic intermediates and products. These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17-20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalFrontiers in Oncology
Volume9
DOIs
Publication statusPublished - Nov 28 2019

Fingerprint

Neoplasms
Slovakia
Tumor Microenvironment
Metabolic Networks and Pathways
Delivery of Health Care
Enzymes
Therapeutics

Keywords

  • cancer imaging
  • cancer metabolism
  • cancer therapy
  • proton dynamics
  • tumor microenvironment

Cite this

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer. / Avnet, Sofia; Baldini, Nicola; Brisson, Lucie; Pedersen, Stine Falsig; Porporato, Paolo E; Sonveaux, Pierre; Szabadkai, Gyorgy; Pastorekova, Silvia.

In: Frontiers in Oncology, Vol. 9, 28.11.2019, p. 1-5.

Research output: Contribution to journalReview article

Avnet, Sofia ; Baldini, Nicola ; Brisson, Lucie ; Pedersen, Stine Falsig ; Porporato, Paolo E ; Sonveaux, Pierre ; Szabadkai, Gyorgy ; Pastorekova, Silvia. / Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer. In: Frontiers in Oncology. 2019 ; Vol. 9. pp. 1-5.
@article{c6d27d5f45444081b6f16446ae126214,
title = "Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer",
abstract = "The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of metabolic enzymes and their upstream regulators and abnormal fluxes of metabolic intermediates and products. These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17-20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.",
keywords = "cancer imaging, cancer metabolism, cancer therapy, proton dynamics, tumor microenvironment",
author = "Sofia Avnet and Nicola Baldini and Lucie Brisson and Pedersen, {Stine Falsig} and Porporato, {Paolo E} and Pierre Sonveaux and Gyorgy Szabadkai and Silvia Pastorekova",
note = "Copyright {\circledC} 2019 Avnet, Baldini, Brisson, Pedersen, Porporato, Sonveaux, Szabadkai and Pastorekova.",
year = "2019",
month = "11",
day = "28",
doi = "10.3389/fonc.2019.01332",
language = "English",
volume = "9",
pages = "1--5",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer

AU - Avnet, Sofia

AU - Baldini, Nicola

AU - Brisson, Lucie

AU - Pedersen, Stine Falsig

AU - Porporato, Paolo E

AU - Sonveaux, Pierre

AU - Szabadkai, Gyorgy

AU - Pastorekova, Silvia

N1 - Copyright © 2019 Avnet, Baldini, Brisson, Pedersen, Porporato, Sonveaux, Szabadkai and Pastorekova.

PY - 2019/11/28

Y1 - 2019/11/28

N2 - The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of metabolic enzymes and their upstream regulators and abnormal fluxes of metabolic intermediates and products. These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17-20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.

AB - The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of metabolic enzymes and their upstream regulators and abnormal fluxes of metabolic intermediates and products. These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17-20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.

KW - cancer imaging

KW - cancer metabolism

KW - cancer therapy

KW - proton dynamics

KW - tumor microenvironment

U2 - 10.3389/fonc.2019.01332

DO - 10.3389/fonc.2019.01332

M3 - Review article

C2 - 31850217

VL - 9

SP - 1

EP - 5

JO - Frontiers in Oncology

JF - Frontiers in Oncology

SN - 2234-943X

ER -