Abstract
Background: Lichenoid dermatoses are composed of a wide spectrum of disorders with a common histopathologic interface pattern but diverse causes and pathophysiology. Objective: We describe a series of young patients with a peculiar annular lichenoid dermatitis, the clinical appearance of which initially suggested diagnoses of morphea, mycosis fungoides, or annular erythema. Results: The study involved 23 patients (median age 10 years; age range 5-22 years). Lesions consisted of persistent asymptomatic erythematous macules and round annular patches with a red-brownish border and central hypopigmentation, mostly distributed on the groin and flanks. Histology revealed a peculiar lichenoid dermatitis with massive necrosis/apoptosis of the keratinocytes limited to the tips of rete ridges, in the absence of dermal sclerosis and epidermotropism of atypical lymphocytes. The infiltrate was composed mainly of memory CD4+ CD30- T cells with few B cells and macrophages niacrophages. Analysis of T-cell receptor-γ-chain gene rearrangement in skin biopsy specimens revealed polyclonality in all the 15 cases studied. Topical and systemic corticosteroids or phototherapy were effective in most patients with relapse after treatment withdrawal. Conclusions: We suggest that this is a distinctive inflammatory condition, and we propose to term it "annular lichenoid dermatitis of youth.
| Original language | English |
|---|---|
| Pages (from-to) | 1029-1036 |
| Number of pages | 8 |
| Journal | Journal of the American Academy of Dermatology |
| Volume | 49 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2003 |
Fingerprint
ASJC Scopus subject areas
- Dermatology
Cite this
Annular lichenoid dermatitis of youth. / Annessi, Giorgio; Paradisi, Mauro; Angelo, Corrado; Perez, Marie; Puddu, Pietro; Girolomoni, Giampiero.
In: Journal of the American Academy of Dermatology, Vol. 49, No. 6, 12.2003, p. 1029-1036.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Annular lichenoid dermatitis of youth
AU - Annessi, Giorgio
AU - Paradisi, Mauro
AU - Angelo, Corrado
AU - Perez, Marie
AU - Puddu, Pietro
AU - Girolomoni, Giampiero
PY - 2003/12
Y1 - 2003/12
N2 - Background: Lichenoid dermatoses are composed of a wide spectrum of disorders with a common histopathologic interface pattern but diverse causes and pathophysiology. Objective: We describe a series of young patients with a peculiar annular lichenoid dermatitis, the clinical appearance of which initially suggested diagnoses of morphea, mycosis fungoides, or annular erythema. Results: The study involved 23 patients (median age 10 years; age range 5-22 years). Lesions consisted of persistent asymptomatic erythematous macules and round annular patches with a red-brownish border and central hypopigmentation, mostly distributed on the groin and flanks. Histology revealed a peculiar lichenoid dermatitis with massive necrosis/apoptosis of the keratinocytes limited to the tips of rete ridges, in the absence of dermal sclerosis and epidermotropism of atypical lymphocytes. The infiltrate was composed mainly of memory CD4+ CD30- T cells with few B cells and macrophages niacrophages. Analysis of T-cell receptor-γ-chain gene rearrangement in skin biopsy specimens revealed polyclonality in all the 15 cases studied. Topical and systemic corticosteroids or phototherapy were effective in most patients with relapse after treatment withdrawal. Conclusions: We suggest that this is a distinctive inflammatory condition, and we propose to term it "annular lichenoid dermatitis of youth.
AB - Background: Lichenoid dermatoses are composed of a wide spectrum of disorders with a common histopathologic interface pattern but diverse causes and pathophysiology. Objective: We describe a series of young patients with a peculiar annular lichenoid dermatitis, the clinical appearance of which initially suggested diagnoses of morphea, mycosis fungoides, or annular erythema. Results: The study involved 23 patients (median age 10 years; age range 5-22 years). Lesions consisted of persistent asymptomatic erythematous macules and round annular patches with a red-brownish border and central hypopigmentation, mostly distributed on the groin and flanks. Histology revealed a peculiar lichenoid dermatitis with massive necrosis/apoptosis of the keratinocytes limited to the tips of rete ridges, in the absence of dermal sclerosis and epidermotropism of atypical lymphocytes. The infiltrate was composed mainly of memory CD4+ CD30- T cells with few B cells and macrophages niacrophages. Analysis of T-cell receptor-γ-chain gene rearrangement in skin biopsy specimens revealed polyclonality in all the 15 cases studied. Topical and systemic corticosteroids or phototherapy were effective in most patients with relapse after treatment withdrawal. Conclusions: We suggest that this is a distinctive inflammatory condition, and we propose to term it "annular lichenoid dermatitis of youth.
UR - http://www.scopus.com/inward/record.url?scp=0345724924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345724924&partnerID=8YFLogxK
U2 - 10.1016/S0190-9622(03)02147-9
DO - 10.1016/S0190-9622(03)02147-9
M3 - Article
C2 - 14639381
AN - SCOPUS:0345724924
VL - 49
SP - 1029
EP - 1036
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 6
ER -