Annular lichenoid dermatitis of youth

Giorgio Annessi, Mauro Paradisi, Corrado Angelo, Marie Perez, Pietro Puddu, Giampiero Girolomoni

Research output: Contribution to journalArticle

Abstract

Background: Lichenoid dermatoses are composed of a wide spectrum of disorders with a common histopathologic interface pattern but diverse causes and pathophysiology. Objective: We describe a series of young patients with a peculiar annular lichenoid dermatitis, the clinical appearance of which initially suggested diagnoses of morphea, mycosis fungoides, or annular erythema. Results: The study involved 23 patients (median age 10 years; age range 5-22 years). Lesions consisted of persistent asymptomatic erythematous macules and round annular patches with a red-brownish border and central hypopigmentation, mostly distributed on the groin and flanks. Histology revealed a peculiar lichenoid dermatitis with massive necrosis/apoptosis of the keratinocytes limited to the tips of rete ridges, in the absence of dermal sclerosis and epidermotropism of atypical lymphocytes. The infiltrate was composed mainly of memory CD4+ CD30- T cells with few B cells and macrophages niacrophages. Analysis of T-cell receptor-γ-chain gene rearrangement in skin biopsy specimens revealed polyclonality in all the 15 cases studied. Topical and systemic corticosteroids or phototherapy were effective in most patients with relapse after treatment withdrawal. Conclusions: We suggest that this is a distinctive inflammatory condition, and we propose to term it "annular lichenoid dermatitis of youth.

Original languageEnglish
Pages (from-to)1029-1036
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume49
Issue number6
DOIs
Publication statusPublished - Dec 2003

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Dermatitis
Hypopigmentation
Localized Scleroderma
T-Cell Receptor Genes
Mycosis Fungoides
Skin
Phototherapy
Groin
Gene Rearrangement
Sclerosis
Keratinocytes
Skin Diseases
Histology
Adrenal Cortex Hormones
B-Lymphocytes
Necrosis
Macrophages
Lymphocytes
Apoptosis
T-Lymphocytes

ASJC Scopus subject areas

  • Dermatology

Cite this

Annessi, G., Paradisi, M., Angelo, C., Perez, M., Puddu, P., & Girolomoni, G. (2003). Annular lichenoid dermatitis of youth. Journal of the American Academy of Dermatology, 49(6), 1029-1036. https://doi.org/10.1016/S0190-9622(03)02147-9

Annular lichenoid dermatitis of youth. / Annessi, Giorgio; Paradisi, Mauro; Angelo, Corrado; Perez, Marie; Puddu, Pietro; Girolomoni, Giampiero.

In: Journal of the American Academy of Dermatology, Vol. 49, No. 6, 12.2003, p. 1029-1036.

Research output: Contribution to journalArticle

Annessi, G, Paradisi, M, Angelo, C, Perez, M, Puddu, P & Girolomoni, G 2003, 'Annular lichenoid dermatitis of youth', Journal of the American Academy of Dermatology, vol. 49, no. 6, pp. 1029-1036. https://doi.org/10.1016/S0190-9622(03)02147-9
Annessi, Giorgio ; Paradisi, Mauro ; Angelo, Corrado ; Perez, Marie ; Puddu, Pietro ; Girolomoni, Giampiero. / Annular lichenoid dermatitis of youth. In: Journal of the American Academy of Dermatology. 2003 ; Vol. 49, No. 6. pp. 1029-1036.
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