Anomalous growth hormone responses to thyrotropin-releasing hormone and glucose in cirrhotic patients: The effect of metergoline

F. Salerno, D. Cocchi, C. Frigerio, A. M. Colombo, E. E. Müller

Research output: Contribution to journalArticlepeer-review

Abstract

The anomalous GH response to TRH or glucose loading was evaluated in patients with severe liver disease untreated or pretreated with metergoline (MCE), a potent antiserotonergic drug. In 9 patients, injection of 400 μg TRH as a bolus induced a clear-cut GH rise (>8 ng/ml), with peak levels 15-90 min post injection. Pretreatment with MCE did not modify baseline GH levels but potentiated the TRH-induced GH rise in 4 patients. In addition, 2 of 8 TRH nonresponder patients developed the anomalous GH response after MCE pretreatment. Like MCE, methysergide, another antiserotoninergic drug, potentiated the TRH-induced GH rise in 2 of 4 patients. Glucose administration (100 g, orally) induced a paradoxical rise of GH in 9 of 10 patients; after MCE, the paradoxical GH response to glucose was potentiated in 6 patients. These data provide the first experimental evidence that a derangement in brain monoamine (serotonin) function is actually involved in the occurrence of anomalous GH responses in subjects with severe liver disease.

Original languageEnglish
Pages (from-to)641-646
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume51
Issue number3
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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