Anomalous vascularization in a Wnt medulloblastoma: A case report

Angela Di Giannatale, Andrea Carai, Antonella Cacchione, Antonio Marrazzo, Vito Andrea Dell'Anna, Giovanna Stefania Colafati, Francesca Diomedi-Camassei, Evelina Miele, Agnese Po, Elisabetta Ferretti, Franco Locatelli, Angela Mastronuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature. Although some studies speculate on the pathogenesis of this anomalous increased vascularization in medulloblastoma, the specific mechanism is still far from clearly understood. A correlation between molecular medulloblastoma subgroups and hemorrhagic features has not been reported, although recent preliminary studies described that WNT-subtype tumors display increased vascularization and hemorrhaging. Case presentation: Herein, we describe a child with a Wnt-medulloblastoma presenting as cerebellar-vermian hemorrhagic lesion. Brain magnetic resonance imaging (MRI) showed the presence of a midline posterior fossa mass with a cystic hemorrhagic component. The differential diagnosis based on imaging included cavernous hemangioma, arteriovenous malformation and traumatic lesion. At surgery, the tumor appeared richly vascularized as documented by the preoperative angiography. Conclusions: The case we present showed that Wnt medulloblastoma may be associated with anomalous vascularization. Further studies are needed to elucidate if there is a link between the hypervascularization and the Wnt/β-catenin signaling activation and if this abnormal vasculature might influence drug penetration contributing to good prognosis of this medulloblastoma subgroup.

Original languageEnglish
Article number103
JournalBMC Neurology
Volume16
Issue number1
DOIs
Publication statusPublished - Jul 15 2016

Keywords

  • Angiogenesis
  • Case report
  • Medulloblastoma
  • Wnt/β-catenin

ASJC Scopus subject areas

  • Clinical Neurology

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