Anorectic effect of fenfluramine isomers and metabolites: Relationship between brain levels and in vitro potencies on serotonergic mechanisms

Tiziana Mennini, Silvio Garattini, Silvio Caccia

Research output: Contribution to journalArticlepeer-review

Abstract

A study of the possible molecular mechanisms of action by which the isomers and metabolites of fenfluramine increase serotonin transmission, leading to anorectic activity, is presented. The actual brain levels of fenfluramine and norfenfluramine isomers after administration of equi-anorectic doses to rats are compared with their potencies in affecting serotonergic mechanisms in vitro. Isomers and metabolites of fenfluramine can have the same pharmacological action by influencing serotonin uptake, release and binding in a quantitatively different manner.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalPsychopharmacology
Volume85
Issue number1
DOIs
Publication statusPublished - Jan 1985

Keywords

  • 5HT binding sites
  • 5HT binding sites
  • Anorectic effect
  • Fenfluramine
  • Serotonin release
  • Serotonin uptake

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'Anorectic effect of fenfluramine isomers and metabolites: Relationship between brain levels and in vitro potencies on serotonergic mechanisms'. Together they form a unique fingerprint.

Cite this