Modificazioni dell'ANP indotte da variazioni del TSH.

Translated title of the contribution: ANP changes induced by varying TSH

I. Testa, C. Rasetti, M. Ippoliti, M. Boni, G. De Sio, A. Recchioni, R. Testa

Research output: Contribution to journalArticlepeer-review


Aim of our study was estimating if TSH could influence the timing of ANP release. About it we observed 70 male subjects: 40 were euthyroid patients aged 42 +/- 5 years (group A); 20 patients treated by thyroxine in doses sufficient for inhibiting TSH release, aged 45 +/- 7 years (group B). A third group (C) was composed by 10 subjects with high basal levels of serum T3 and T4 with no thyrostatic therapy, aged 40 +/- 9 years. These subjects underwent a TRH test estimating at -30', 0', 30', 60', 120' plasma concentrations of TSH, ANP, T3, T4. In reply to physiological stimulus induced on patients of group A we observed a significant increase of TSH values (max at 60') and ANP levels (max at 120'). No significant variations occurred during the TRH test in T3 and T4 concentrations. In groups B and C no important modifications were observed neither in TSH nor in ANP plasma levels. ANP secretion seems to be dependent from the secretory condition of hypothalamus-pituitary-thyroid axis both in physiological and pathological conditions.

Translated title of the contributionANP changes induced by varying TSH
Original languageItalian
Pages (from-to)25-31
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Issue number1
Publication statusPublished - Jan 1993

ASJC Scopus subject areas

  • Medicine(all)


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