Abstract
In this study we show that cytarabine given simultaneously with 5-aza-2'-deoxycytidine (Aza-dC) antagonized Aza-dC activity against L1210 mouse leukemia. This antagonism was seen after a single dose (on Day 3 or Day 5 after tumor implant) and after repeated doses. This observation suggests caution in combining cytarabine with Aza-dC in the treatment of human leukemias.
| Original language | English |
|---|---|
| Pages (from-to) | 1451-1453 |
| Number of pages | 3 |
| Journal | Cancer Treatment Reports |
| Volume | 70 |
| Issue number | 12 |
| Publication status | Published - 1986 |
ASJC Scopus subject areas
- Cancer Research
- Oncology
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Colombo, T., Rossi, C., & D'Incalci, M. (1986). Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine. Cancer Treatment Reports, 70(12), 1451-1453.