Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine

T. Colombo, C. Rossi, M. D'Incalci

Research output: Contribution to journalArticle

Abstract

In this study we show that cytarabine given simultaneously with 5-aza-2'-deoxycytidine (Aza-dC) antagonized Aza-dC activity against L1210 mouse leukemia. This antagonism was seen after a single dose (on Day 3 or Day 5 after tumor implant) and after repeated doses. This observation suggests caution in combining cytarabine with Aza-dC in the treatment of human leukemias.

Original languageEnglish
Pages (from-to)1451-1453
Number of pages3
JournalCancer Treatment Reports
Volume70
Issue number12
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine'. Together they form a unique fingerprint.

  • Cite this