Antagonism of eegraphic and behavioural effects of methamphetamine by selective receptor blockers (SCH 23390 and raclopride) in the rabbit

Paola Bo, Enrico Marchioni, Carlo Dallocchio, Andrea Albergati, Faustino Savoldi

Research output: Contribution to journalArticlepeer-review

Abstract

1. The interactions between selective D1 and D2 antagonists (SCH 23390 and raclopride) and methamphetamine on EEG arousal and behaviour was studied in rabbits. Haloperidol, a "classic neuroleptic" was used as reference drug. 2. Both 23390 and raclopride, which were used at low dosage (0.03-0.09 mg/kg iv for the former and 1-3 mg/kg for the latter), were able to block completely the behaviour induced but do not inhibit completely the EEG arousal pattern induced by methamphetamine. 3. The blockade of both behaviour and EEG arousal took only when the two drugs were administered concomitantly at the lower dosage. 4. The antagonistic effects obtained with the concomitantly administration of the two drugs were of higher degree in confront of those obtained with the pretreatment with haloperidol 0.3 mg/kg iv. 5. Our data indicate that both D1 and D2 antagonists are able to block, at the dosage used, motor hyperactivity and stereotyped behaviour typically induced by methamphetamine and that SCH 23390 and raclopride are potentiated also in this experimental model.

Original languageEnglish
Pages (from-to)803-815
Number of pages13
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume15
Issue number6
DOIs
Publication statusPublished - 1991

Keywords

  • behaviour
  • D1 and D2 dopamine antagonists
  • methamphetamine
  • rabbit EEG

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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