Abstract
The effect of 1-(2-pyrimidinyl)piperazine (PmP), the main metabolite of buspirone, was tested on K+-evoked [3H]noradrenaline and [3H]serotonin release from superfused synaptosomes obtained from rat cerebral cortex. PmP had no effects per se, but antagonized the effect of noradrenaline, producing a parallel shift to the right of the noradrenaline inhibition curves. From these data pA2 (apparent affinity) values of 6.8 and 7.3 were calculated for PmP on presynaptic α2-adrenoceptors located on noradrenergic and serotonergic nerve terminals, respectively.
Original language | English |
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Pages (from-to) | 183-186 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 180 |
Issue number | 1 |
DOIs | |
Publication status | Published - May 3 1990 |
Keywords
- PmP (1-(2-pyrimidinyl)piperazine)
- Synaptosomes
- [H]5-HT release
- α-Adrenoceptors
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology