The effect of 1-(2-pyrimidinyl)piperazine (PmP), the main metabolite of buspirone, was tested on K+-evoked [3H]noradrenaline and [3H]serotonin release from superfused synaptosomes obtained from rat cerebral cortex. PmP had no effects per se, but antagonized the effect of noradrenaline, producing a parallel shift to the right of the noradrenaline inhibition curves. From these data pA2 (apparent affinity) values of 6.8 and 7.3 were calculated for PmP on presynaptic α2-adrenoceptors located on noradrenergic and serotonergic nerve terminals, respectively.
- PmP (1-(2-pyrimidinyl)piperazine)
- [H]5-HT release
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience