Antagonist properties of 1-(2-pyrimidinyl) piperazine at presynaptic α2-adrenoceptors in the rat brain

Marco Gobbi, Emanuela Frittoli, Tiziana Mennini

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of 1-(2-pyrimidinyl)piperazine (PmP), the main metabolite of buspirone, was tested on K+-evoked [3H]noradrenaline and [3H]serotonin release from superfused synaptosomes obtained from rat cerebral cortex. PmP had no effects per se, but antagonized the effect of noradrenaline, producing a parallel shift to the right of the noradrenaline inhibition curves. From these data pA2 (apparent affinity) values of 6.8 and 7.3 were calculated for PmP on presynaptic α2-adrenoceptors located on noradrenergic and serotonergic nerve terminals, respectively.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalEuropean Journal of Pharmacology
Volume180
Issue number1
DOIs
Publication statusPublished - May 3 1990

Keywords

  • PmP (1-(2-pyrimidinyl)piperazine)
  • Synaptosomes
  • [H]5-HT release
  • α-Adrenoceptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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