Antenatal and delivery risk factors simultaneously associated with neonatal death and cerebral palsy in preterm infants

Arsenio Spinillo, Ezio Capuzzo, Simona Orcesi, Mauro Stronati, Marco Di Mario, Elisa Fazzi

Research output: Contribution to journalArticlepeer-review


To evaluate the simultaneous effects of antenatal and delivery risk factors on neonatal death and cerebral palsy in preterm infants, we conducted a cohort study of 363 singleton pregnancies delivered between 24 and 33 weeks gestation. Neurodevelopmental outcome of the infants was evaluated at 2 years of corrected age. Risk factors associated with death or cerebral palsy were analysed by politomous logistic regression. Overall, the mortality rate was 14.6% (53/363) and the prevalence of cerebral palsy among surviving infants was 12.3% (38/310). Decreasing gestation and meconium-stained amniotic fluid were the only antenatal factors associated with increased odds for both death and cerebral palsy. The effect magnitude and the predictive value of gestational age were greater for death than for cerebral palsy. After adjustment for confounders, prolonged (≤ 48 h) rupture of membranes (odds ratio 2.98, 95% confidence interval 1.12-7.96) and male sex of the infant (odds ratio 3.01, 95% confidence interval 1.32-6.71) were significantly associated only with cerebral palsy. We conclude that neonatal death and cerebral palsy share few common antenatal risk factors. The characteristics of antenatal risk factors for cerebral palsy suggest that bacterial infestation of the amniotic cavity may be implicated in the etiology of the cerebral impairment.

Original languageEnglish
Pages (from-to)81-91
Number of pages11
JournalEarly Human Development
Issue number1-2
Publication statusPublished - Apr 25 1997


  • Cerebral palsy
  • Neonatal death
  • Risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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