Antenatal post-hemorrhagic ventriculomegaly: A prospective follow-up study

R. Luciano, G. Baranello, L. Masini, D. Ricci, F. Gallini, S. Ciotti, D. Leone, F. Serrao, M. De Santis, E. Zecca, A. Zuppa, C. Romagnoli, C. Di Rocco, F. Guzzetta, E. Mercuri

Research output: Contribution to journalArticlepeer-review


Objective: The aim of this study was to evaluate the presence and the severity of neurological and cognitive impairment at 2 years of age in 16 infants (9 term born, 7 preterm of mean gestation 33.6 weeks) with cerebral ventriculomegaly of antenatal onset associated with intraventricular haemorrhage. Methods: Ventricular dilatation, with or without associated lesions, was, with one exception, not identified on the antenatal routine scan at approximately 22 weeks but was obvious on the scans performed between weeks 27 and 33. In 8 of the 16 cases there were signs of parenchymal involvement or of abnormalities of the corpus callosum or cerebellum. In all patients the diagnosis of antenatal IVH was confirmed by early neonatal imaging. Outcome was measured using the Hammersmith infant neurological examination and the Griffiths developmental scales at 2 years. Results and Conclusions: At 2 years, 8 infants had normal motor outcome and 8 had cerebral palsy. The presence and severity of cerebral palsy or neurodevelopmental delay was not always related to the magnitude or symmetry of the ventricular dilatation per se. The presence of associated lesions was a negative prognostic marker. The early development of epilepsy was also associated with an abnormal outcome.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
Issue number3
Publication statusPublished - Jun 2007


  • Antenatal status
  • Outcome
  • Post-haemorrhagic status
  • Ventriculomegaly

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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