Antenatal steroids and risk of bronchopulmonary dysplasia: A lack of effect or a case of over-adjustment?

Luigi Gagliardi; Roberto Bellù; Franca Rusconi; Daniele Merazzi; Fabio Mosca; A. Cavazza; A. Brunelli; M. Battaglioli; F. Tandoi; D. Cella; G. F. Perotti; M. Pelti; I. Stucchi; F. Frisone; A. Avanzini; P. Bastrenta; G. Iacono; F. Pontiggia; G. Chirico; A. Cotta-Ramusino; S. Martinelli; F. Strano; P. Fontana; G. Compagnoni; M. Franco; L. Rossi; M. L. Caccamo; M. Agosti; G. Calciolari; G. Citterio; R. Rovelli; A. Poloniato; G. Barera; G. P. Gancia; G. Rondini; C. Costato; R. Germani; M. Maccabruni; S. Barp; R. Crossignani; S. Santucci; R. Zanini; N. Siliprandi; C. Borroni; M. L. Ventura; L. Abbiati; S. Giardinetti; L. Leva; M. Fusi; M. Bellasio

doi:10.1111/j.1365-3016.2007.00814.x

Antenatal steroids and risk of bronchopulmonary dysplasia: A lack of effect or a case of over-adjustment?

Luigi Gagliardi, Roberto Bellù, Franca Rusconi, Daniele Merazzi, Fabio Mosca, A. Cavazza, A. Brunelli, M. Battaglioli, F. Tandoi, D. Cella, G. F. Perotti, M. Pelti, I. Stucchi, F. Frisone, A. Avanzini, P. Bastrenta, G. Iacono, F. Pontiggia, G. Chirico, A. Cotta-RamusinoS. Martinelli, F. Strano, P. Fontana, G. Compagnoni, M. Franco, L. Rossi, M. L. Caccamo, M. Agosti, G. Calciolari, G. Citterio, R. Rovelli, A. Poloniato, G. Barera, G. P. Gancia, G. Rondini, C. Costato, R. Germani, M. Maccabruni, S. Barp, R. Crossignani, S. Santucci, R. Zanini, N. Siliprandi, C. Borroni, M. L. Ventura, L. Abbiati, S. Giardinetti, L. Leva, M. Fusi, M. Bellasio

Research output: Contribution to journal › Article

Abstract

Although antenatal steroids reduce risk factors for bronchopulmonary dysplasia (BPD) in preterm infants, their effect on BPD is conflicting. We hypothesised that the lack of protective effect found in some studies could derive from over-adjustment during analysis, caused by controlling for factors intermediate in the causal pathway between treatment and outcome. We prospectively studied a cohort of infants 23-32 weeks gestation

Original language	English
Pages (from-to)	347-353
Number of pages	7
Journal	Paediatric and Perinatal Epidemiology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-3016.2007.00814.x
Publication status	Published - Jul 2007

Keywords

Antenatal betamethasone
Antenatal steroid medication
Bronchopulmonary dysplasia
Statistical over-control

ASJC Scopus subject areas

Epidemiology
Pediatrics, Perinatology, and Child Health

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Gagliardi, L., Bellù, R., Rusconi, F., Merazzi, D., Mosca, F., Cavazza, A., Brunelli, A., Battaglioli, M., Tandoi, F., Cella, D., Perotti, G. F., Pelti, M., Stucchi, I., Frisone, F., Avanzini, A., Bastrenta, P., Iacono, G., Pontiggia, F., Chirico, G., ... Bellasio, M. (2007). Antenatal steroids and risk of bronchopulmonary dysplasia: A lack of effect or a case of over-adjustment? Paediatric and Perinatal Epidemiology, 21(4), 347-353. https://doi.org/10.1111/j.1365-3016.2007.00814.x

Antenatal steroids and risk of bronchopulmonary dysplasia : A lack of effect or a case of over-adjustment? / Gagliardi, Luigi; Bellù, Roberto; Rusconi, Franca; Merazzi, Daniele; Mosca, Fabio; Cavazza, A.; Brunelli, A.; Battaglioli, M.; Tandoi, F.; Cella, D.; Perotti, G. F.; Pelti, M.; Stucchi, I.; Frisone, F.; Avanzini, A.; Bastrenta, P.; Iacono, G.; Pontiggia, F.; Chirico, G.; Cotta-Ramusino, A.; Martinelli, S.; Strano, F.; Fontana, P.; Compagnoni, G.; Franco, M.; Rossi, L.; Caccamo, M. L.; Agosti, M.; Calciolari, G.; Citterio, G.; Rovelli, R.; Poloniato, A.; Barera, G.; Gancia, G. P.; Rondini, G.; Costato, C.; Germani, R.; Maccabruni, M.; Barp, S.; Crossignani, R.; Santucci, S.; Zanini, R.; Siliprandi, N.; Borroni, C.; Ventura, M. L.; Abbiati, L.; Giardinetti, S.; Leva, L.; Fusi, M.; Bellasio, M.

In: Paediatric and Perinatal Epidemiology, Vol. 21, No. 4, 07.2007, p. 347-353.

Research output: Contribution to journal › Article

Gagliardi, L, Bellù, R, Rusconi, F, Merazzi, D, Mosca, F, Cavazza, A, Brunelli, A, Battaglioli, M, Tandoi, F, Cella, D, Perotti, GF, Pelti, M, Stucchi, I, Frisone, F, Avanzini, A, Bastrenta, P, Iacono, G, Pontiggia, F, Chirico, G, Cotta-Ramusino, A, Martinelli, S, Strano, F, Fontana, P, Compagnoni, G, Franco, M, Rossi, L, Caccamo, ML, Agosti, M, Calciolari, G, Citterio, G, Rovelli, R, Poloniato, A, Barera, G, Gancia, GP, Rondini, G, Costato, C, Germani, R, Maccabruni, M, Barp, S, Crossignani, R, Santucci, S, Zanini, R, Siliprandi, N, Borroni, C, Ventura, ML, Abbiati, L, Giardinetti, S, Leva, L, Fusi, M & Bellasio, M 2007, 'Antenatal steroids and risk of bronchopulmonary dysplasia: A lack of effect or a case of over-adjustment?', Paediatric and Perinatal Epidemiology, vol. 21, no. 4, pp. 347-353. https://doi.org/10.1111/j.1365-3016.2007.00814.x

Gagliardi, Luigi ; Bellù, Roberto ; Rusconi, Franca ; Merazzi, Daniele ; Mosca, Fabio ; Cavazza, A. ; Brunelli, A. ; Battaglioli, M. ; Tandoi, F. ; Cella, D. ; Perotti, G. F. ; Pelti, M. ; Stucchi, I. ; Frisone, F. ; Avanzini, A. ; Bastrenta, P. ; Iacono, G. ; Pontiggia, F. ; Chirico, G. ; Cotta-Ramusino, A. ; Martinelli, S. ; Strano, F. ; Fontana, P. ; Compagnoni, G. ; Franco, M. ; Rossi, L. ; Caccamo, M. L. ; Agosti, M. ; Calciolari, G. ; Citterio, G. ; Rovelli, R. ; Poloniato, A. ; Barera, G. ; Gancia, G. P. ; Rondini, G. ; Costato, C. ; Germani, R. ; Maccabruni, M. ; Barp, S. ; Crossignani, R. ; Santucci, S. ; Zanini, R. ; Siliprandi, N. ; Borroni, C. ; Ventura, M. L. ; Abbiati, L. ; Giardinetti, S. ; Leva, L. ; Fusi, M. ; Bellasio, M. / Antenatal steroids and risk of bronchopulmonary dysplasia : A lack of effect or a case of over-adjustment?. In: Paediatric and Perinatal Epidemiology. 2007 ; Vol. 21, No. 4. pp. 347-353.

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abstract = "Although antenatal steroids reduce risk factors for bronchopulmonary dysplasia (BPD) in preterm infants, their effect on BPD is conflicting. We hypothesised that the lack of protective effect found in some studies could derive from over-adjustment during analysis, caused by controlling for factors intermediate in the causal pathway between treatment and outcome. We prospectively studied a cohort of infants 23-32 weeks gestation ",

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