Antenatal steroids and risk of bronchopulmonary dysplasia: A lack of effect or a case of over-adjustment?

Luigi Gagliardi, Roberto Bellù, Franca Rusconi, Daniele Merazzi, Fabio Mosca, A. Cavazza, A. Brunelli, M. Battaglioli, F. Tandoi, D. Cella, G. F. Perotti, M. Pelti, I. Stucchi, F. Frisone, A. Avanzini, P. Bastrenta, G. Iacono, F. Pontiggia, G. Chirico, A. Cotta-RamusinoS. Martinelli, F. Strano, P. Fontana, G. Compagnoni, M. Franco, L. Rossi, M. L. Caccamo, M. Agosti, G. Calciolari, G. Citterio, R. Rovelli, A. Poloniato, G. Barera, G. P. Gancia, G. Rondini, C. Costato, R. Germani, M. Maccabruni, S. Barp, R. Crossignani, S. Santucci, R. Zanini, N. Siliprandi, C. Borroni, M. L. Ventura, L. Abbiati, S. Giardinetti, L. Leva, M. Fusi, M. Bellasio

Research output: Contribution to journalArticle

Abstract

Although antenatal steroids reduce risk factors for bronchopulmonary dysplasia (BPD) in preterm infants, their effect on BPD is conflicting. We hypothesised that the lack of protective effect found in some studies could derive from over-adjustment during analysis, caused by controlling for factors intermediate in the causal pathway between treatment and outcome. We prospectively studied a cohort of infants 23-32 weeks gestation

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalPaediatric and Perinatal Epidemiology
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Antenatal betamethasone
  • Antenatal steroid medication
  • Bronchopulmonary dysplasia
  • Statistical over-control

ASJC Scopus subject areas

  • Epidemiology
  • Pediatrics, Perinatology, and Child Health

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  • Cite this

    Gagliardi, L., Bellù, R., Rusconi, F., Merazzi, D., Mosca, F., Cavazza, A., Brunelli, A., Battaglioli, M., Tandoi, F., Cella, D., Perotti, G. F., Pelti, M., Stucchi, I., Frisone, F., Avanzini, A., Bastrenta, P., Iacono, G., Pontiggia, F., Chirico, G., ... Bellasio, M. (2007). Antenatal steroids and risk of bronchopulmonary dysplasia: A lack of effect or a case of over-adjustment? Paediatric and Perinatal Epidemiology, 21(4), 347-353. https://doi.org/10.1111/j.1365-3016.2007.00814.x