TY - JOUR
T1 - Anterior Callosal Angle
T2 - A New Marker of Idiopathic Normal Pressure Hydrocephalus?
AU - BOLOGNA PRO-HYDRO Study Group
AU - Mantovani, Paolo
AU - Albini-Riccioli, Luca
AU - Giannini, Giulia
AU - Milletti, David
AU - Sorenson, Thomas J.
AU - Stanzani-Maserati, Michelangelo
AU - Oppi, Federico
AU - Elder, Benjamin D.
AU - Cevoli, Sabina
AU - Cortelli, Pietro
AU - Palandri, Giorgio
AU - Agati, Raffaele
AU - Calandra-Buonaura, Giovanna
AU - Capellari, Sabina
AU - Chiari, Lorenzo
AU - Ferrari, Alberto
AU - Merola, Margherita
AU - Parchi, Piero
AU - Pirina, Alessandro
AU - Piserchia, Vito Antonio
AU - Ricci, Valentina
AU - Sambati, Luisa
AU - Sturiale, Carmelo
AU - Supino, Antonella
N1 - Ricercatore distaccato presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Cortelli Pietro)
PY - 2020/7
Y1 - 2020/7
N2 - Objective: Diagnosing idiopathic normal pressure hydrocephalus (iNPH) still remains a clinical challenge. The callosal angle (CA) is a widely used neuroradiologic marker for iNPH. However, the relationship of the CA to clinical features has not been well investigated. We hypothesize that iNPH symptoms might better correlate with a variant of the CA (anterior callosal angle [ACA]). We aim to establish the validity of the ACA measurement for the diagnosis of iNPH and compare it with current radiologic parameters. Methods: The multidisciplinary BOLOGNA PRO-HYDRO Study Group performed a retrospective review of consecutive iNPH patients. Magnetic resonance imaging studies for these patients were collected, as well as magnetic resonance imaging studies from Alzheimer disease and healthy control patients. The CA, ACA, and Evans Index were measured by 2 blinded members of the study team based on magnetic resonance images for each of these populations. Results: The ACA shows high accuracy, sensitivity, and specificity in distinguishing iNPH patients from healthy control and Alzheimer disease patients. The optimal pathologic diagnostic cut-off value for the ACA is 119 degrees. The diagnostic accuracy of the ACA is not significantly different from the CA. Conclusions: The ACA could be a valid radiologic parameter in the diagnostic armamentarium for iNPH.
AB - Objective: Diagnosing idiopathic normal pressure hydrocephalus (iNPH) still remains a clinical challenge. The callosal angle (CA) is a widely used neuroradiologic marker for iNPH. However, the relationship of the CA to clinical features has not been well investigated. We hypothesize that iNPH symptoms might better correlate with a variant of the CA (anterior callosal angle [ACA]). We aim to establish the validity of the ACA measurement for the diagnosis of iNPH and compare it with current radiologic parameters. Methods: The multidisciplinary BOLOGNA PRO-HYDRO Study Group performed a retrospective review of consecutive iNPH patients. Magnetic resonance imaging studies for these patients were collected, as well as magnetic resonance imaging studies from Alzheimer disease and healthy control patients. The CA, ACA, and Evans Index were measured by 2 blinded members of the study team based on magnetic resonance images for each of these populations. Results: The ACA shows high accuracy, sensitivity, and specificity in distinguishing iNPH patients from healthy control and Alzheimer disease patients. The optimal pathologic diagnostic cut-off value for the ACA is 119 degrees. The diagnostic accuracy of the ACA is not significantly different from the CA. Conclusions: The ACA could be a valid radiologic parameter in the diagnostic armamentarium for iNPH.
KW - Alzheimer disease
KW - Anterior callosal angle
KW - Callosal angle
KW - Idiopathic normal pressure hydrocephalus
KW - Magnetic resonance imaging
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U2 - 10.1016/j.wneu.2020.04.085
DO - 10.1016/j.wneu.2020.04.085
M3 - Article
C2 - 32348895
AN - SCOPUS:85085755603
VL - 139
SP - e548-e552
JO - World Neurosurgery
JF - World Neurosurgery
SN - 1878-8750
ER -