Anterior Chamber Inflammation After Cataract Surgery: A Randomized Clinical Trial Comparing Bromfenac 0.09% to Dexamethasone 0.1%

Marco Coassin, Michele De Maria, Valentina Mastrofilippo, Luca Braglia, Luca Cimino, Antonio Sartori, Luigi Fontana

Research output: Contribution to journalArticle


Purpose: To compare the efficacy of bromfenac 0.09% and dexamethasone 0.1% in the treatment of anterior chamber inflammation after uncomplicated cataract surgery. Methods: Seventy-six patients with senile cataracts and no other ocular comorbidities who underwent uneventful phacoemulsification were randomized 1:1 to receive dexamethasone ophthalmic suspension 0.1% or bromfenac ophthalmic solution 0.09% for 2 weeks. All patients were examined on the day before surgery and postoperatively at day 1, 3, 7, 9, 11, 14 and 30. Laser flare photometry was used to quantify anterior chamber inflammation and optical coherence tomography to measure macular thickness. Results: Bromfenac was as effective as dexamethasone in reducing inflammation in the anterior chamber of the eye. Laser flare increased the day after surgery and progressively decreased after starting the treatment with no statistically significant difference between dexamethasone and bromfenac at all time points. Visual acuity improved steadily after surgery in both groups. Mean macular thickness was similar in both the dexamethasone and bromfenac arms at 1 month. Conclusions: Short-term therapy with topical bromfenac alone is as effective as dexamethasone in low-risk cataract surgery patients. Trial Registration: # NCT03317847; EudraCT # 2016-004358-14. Funding: Santa Maria Nuova Hospital IRCCS, Reggio Emilia, Italy.

Original languageEnglish
JournalAdvances in Therapy
Publication statusAccepted/In press - Jan 1 2019



  • Cataract surgery
  • Laser flare photometry
  • Non-steroidal anti-inflammatory drugs
  • Ophthalmology

ASJC Scopus subject areas

  • Pharmacology (medical)

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