Anterior craniofacial resection for malignant paranasal tumors

A monoinstitutional experience of 366 cases

Giulio Cantu, Carlo L. Solero, Rosalba Miceli, Flavia Mattana, Stefano Riccio, Sarah Colombo, Madia Pompilio, Giuseppe Lombardo, Paolo Formillo, Pasquale Quattrone

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. The purpose of this study was to evaluate the results of a mono-institutional series of patients treated with anterior craniofacial resection for malignant paranasal sinus tumors. Methods. We analyzed all patients with malignant paranasal sinus tumors treated with anterior craniofacial resection at our institution between 1987 and 2007. All tumors were classified according to both the American Joint Committee on Cancer (AJCC)-2002 and the Istituto Nazionale Tumori (INT) classifications. Results. The sample included 366 patients. There was intraorbital spread in 108 cases. The skull base was eroded in 127 patients, with dura or brain involvement in 93 patients. The 10-year disease-specific survival was 53.1%. Histologic subtype, INT stage, surgical margins, and postsurgical radiotherapy were significant, independent predictors for both local relapse and disease-specific survival (DSS). The AJCC-2002 classification was not significant when tested in place of INT stage. Conclusion. Our data indicated that craniofacial resection and postsurgical radiotherapy remain the primary option for malignant tumors involving the anterior skull base.

Original languageEnglish
Pages (from-to)78-87
Number of pages10
JournalHead and Neck
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Neoplasms
Paranasal Sinuses
Skull Base
Radiotherapy
Survival
Recurrence
Brain
Margins of Excision

Keywords

  • anterior skull base surgery
  • craniofacial resection
  • malignant tumors
  • multivariable analysis
  • paranasal sinus

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Anterior craniofacial resection for malignant paranasal tumors : A monoinstitutional experience of 366 cases. / Cantu, Giulio; Solero, Carlo L.; Miceli, Rosalba; Mattana, Flavia; Riccio, Stefano; Colombo, Sarah; Pompilio, Madia; Lombardo, Giuseppe; Formillo, Paolo; Quattrone, Pasquale.

In: Head and Neck, Vol. 34, No. 1, 01.2012, p. 78-87.

Research output: Contribution to journalArticle

Cantu, G, Solero, CL, Miceli, R, Mattana, F, Riccio, S, Colombo, S, Pompilio, M, Lombardo, G, Formillo, P & Quattrone, P 2012, 'Anterior craniofacial resection for malignant paranasal tumors: A monoinstitutional experience of 366 cases', Head and Neck, vol. 34, no. 1, pp. 78-87. https://doi.org/10.1002/hed.21685
Cantu, Giulio ; Solero, Carlo L. ; Miceli, Rosalba ; Mattana, Flavia ; Riccio, Stefano ; Colombo, Sarah ; Pompilio, Madia ; Lombardo, Giuseppe ; Formillo, Paolo ; Quattrone, Pasquale. / Anterior craniofacial resection for malignant paranasal tumors : A monoinstitutional experience of 366 cases. In: Head and Neck. 2012 ; Vol. 34, No. 1. pp. 78-87.
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