Abstract
Original language | English |
---|---|
Pages (from-to) | 55-60 |
Number of pages | 6 |
Journal | Neurobiol. Aging |
Volume | 93 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Dementia with Lewy bodies
- EEG rhythms
- Thalamocortical dysfunctions
- aged
- alpha rhythm
- Alzheimer disease
- Article
- brain cortex
- cognitive defect
- cohort analysis
- controlled study
- delta rhythm
- diffuse Lewy body disease
- dominant frequency
- EEG abnormality
- electroencephalogram
- electroencephalography
- Europe
- female
- human
- major clinical study
- male
- prealpha rhythm
- priority journal
- thalamocortical dysrhythmia
- theta rhythm
- brain
- clinical trial
- cognition
- differential diagnosis
- multicenter study
- pathophysiology
- psychology
- very elderly
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Brain
- Cognition
- Cohort Studies
- Diagnosis, Differential
- Electroencephalography
- Female
- Humans
- Lewy Body Disease
- Male
Access to Document
Fingerprint Dive into the research topics of 'Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study'. Together they form a unique fingerprint.
Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study. / Franciotti, R.; Pilotto, A.; Moretti, D.V.; Falasca, N.W.; Arnaldi, D.; Taylor, J.-P.; Nobili, F.; Kramberger, M.; Ptacek, S.G.; Padovani, A.; Aarlsand, D.; Onofrj, M.; Bonanni, L.; consortium, E-DLB.
In: Neurobiol. Aging, Vol. 93, 2020, p. 55-60.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Anterior EEG slowing in dementia with Lewy bodies:
T2 - a multicenter European cohort study
AU - Franciotti, R.
AU - Pilotto, A.
AU - Moretti, D.V.
AU - Falasca, N.W.
AU - Arnaldi, D.
AU - Taylor, J.-P.
AU - Nobili, F.
AU - Kramberger, M.
AU - Ptacek, S.G.
AU - Padovani, A.
AU - Aarlsand, D.
AU - Onofrj, M.
AU - Bonanni, L.
AU - consortium, E-DLB
N1 - Cited By :3 Export Date: 23 February 2021 CODEN: NEAGD Correspondence Address: Bonanni, L.; Department of Neuroscience, Via dei Vestini, Italy; email: l.bonanni@unich.it Funding details: National Institute for Health Research, NIHR Funding details: South London and Maudsley NHS Foundation Trust Funding details: King’s College London Funding text 1: This paper represents independent research partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. References: Antelmi, E., Ferri, R., Iranzo, A., Arnulf, I., Dauvilliers, Y., Bhatia, K.P., Liguori, R., Plazzi, G., From state dissociation to status dissociatus (2016) Sleep Med. Rev., 28, pp. 5-17; Bonanni, L., Franciotti, R., Nobili, F., Kramberger, M.G., Taylor, J.P., Garcia-Ptacek, S., Falasca, N.W., Aarsland, D., EEG Markers of dementia with Lewy bodies: a multicenter cohort study (2016) J. Alzheimers Dis., 54, pp. 1649-1657; Bonanni, L., Perfetti, B., Bifolchetti, S., Taylor, J.P., Franciotti, R., Parnetti, L., Thomas, A., Onofrj, M., Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies (2015) Neurobiol. Aging, 36, pp. 434-445; Bonanni, L., Thomas, A., Tiraboschi, P., Perfetti, B., Varanese, S., Onofrj, M., EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up (2008) Brain, 131, pp. 690-705; Caviness, J.N., Hentz, J.G., Evidente, V.G., Driver-Dunckley, E., Samanta, J., Mahant, P., Connor, D.J., Adler, C.H., Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease (2007) Parkinsonism Relat. Disord., 13, pp. 348-354; Chiang, A.K., Rennie, C.J., Robinson, P.A., Roberts, J.A., Rigozzi, M.K., Whitehouse, R.W., Hamilton, R.J., Gordon, E., Automated characterization of multiple alpha peaks in multi-site electroencephalograms (2008) J. Neurosci. Meth., 168, pp. 396-411; Cozac, V.V., Gschwandtner, U., Hatz, F., Hardmeier, M., Rüegg, S., Fuhr, P., Quantitative EEG and cognitive Decline in Parkinson's disease (2016) Parkinsons Dis., p. 9060649; Cummings, J.L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D.A., Gornbein, J., The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia (1994) Neurology, 44, pp. 2308-2314; Delli Pizzi, S., Franciotti, R., Taylor, J.P., Esposito, R., Tartaro, A., Thomas, A., Onofrj, M., Bonanni, L., Structural connectivity is differently altered in dementia with Lewy body and Alzheimer's disease (2015) Front. Aging Neurosci., 7, p. 208; Delli Pizzi, S., Franciotti, R., Taylor, J.P., Thomas, A., Tartaro, A., Onofrj, M., Bonanni, L., Thalamic Involvement in fluctuating cognition in dementia with Lewy bodies: Magnetic Resonance Evidences (2015) Cereb. Cortex, 25, pp. 3682-3689; Delli Pizzi, S., Maruotti, V., Taylor, J.P., Franciotti, R., Caulo, M., Tartaro, A., Thomas, A., Bonanni, L., Relevance of subcortical visual pathways disruption to visual symptoms in dementia with Lewy bodies (2014) Cortex, 59, pp. 12-21; Fiset, P., Paus, T., Daloze, T., Plourde, G., Meuret, P., Bonhomme, V., Hajj-Ali, N., Evans, A.C., Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study (1999) J. Neurosci., 19, pp. 5506-5513; Foucher, J.R., Otzenberger, H., Gounot, D., Where arousal meets attention: a simultaneous fMRI and EEG recording study (2004) Neuroimage, 22, pp. 688-697; Garn, H., Coronel, C., Waser, M., Caravias, G., Ransmayr, G., Differential diagnosis between patients with probable Alzheimer's disease, Parkinson's disease dementia, or dementia with Lewy bodies and frontotemporal dementia, behavioral variant, using quantitative electroencephalographic features (2017) J. Neural Transm., 124, pp. 569-581; Kenny, E.R., O'Brien, J.T., Firbank, M.J., Blamire, A.M., Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease (2013) Br. J. Psychiatry, 203, pp. 209-214; Llinás, R.R., Ribary, U., Jeanmonod, D., Kronberg, E., Mitra, P.P., Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography (1999) Proc. Natl. Acad. Sci. U. S. A., 96, pp. 15222-15227; Llinás, R.R., Steriade, M., Bursting of thalamic neurons and states of vigilance (2006) J. Neurophysiol., 95, pp. 3297-3308; McKeith, I.G., Boeve, B.F., Dickson, D.W., Halliday, G., Taylor, J.P., Weintraub, D., Aarsland, D., Kosaka, K., Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium (2017) Neurology, 89, pp. 88-100; McKeith, I.G., Dickson, D.W., Lowe, J., Emre, M., O'Brien, J.T., Feldman, H., Cummings, J., Consortium on DLB, Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium (2005) Neurology, 65, pp. 1863-1872; McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R., Jr., Kawas, C.H., Klunk, W.E., Phelps, C.H., The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease (2011) Alzheimers Dement., 7, pp. 263-269; Niedermeyer, E., Lopes Da Silva, F.H., Electroencephalography: Basic Principles, Clinical Applications, and Related Fields (2005), Lippincott and Williams Baltimore, Maryland; Onofrj, M., Thomas, A., Iacono, D., Luciano, A.L., Di Iorio, A., The effects of a cholinesterase inhibitor are prominent in patients with fluctuating cognition: a part 3 study of the main mechanism of cholinesterase inhibitors in dementia (2003) Clin. Neuropharmacol., 26, pp. 239-251; Perry, E., Walker, M., Grace, J., Perry, R., Acetylcholine in mind: a neurotransmitter correlate of consciousness? (1999) Trends Neurosci., 22, pp. 273-280; Pilotto, A., Schiano di Cola, F., Premi, E., Grasso, R., Turrone, R., Gipponi, S., Scalvini, A., Padovani, A., Extrastriatal dopaminergic and serotonergic pathways in Parkinson's disease and in dementia with Lewy bodies: a 123I-FP-CIT SPECT study (2019) Eur. J. Nucl. Med. Mol. Imaging, 46, pp. 1642-1651; Robinson, P.A., Whitehouse, R.W., Rennie, C.J., Nonuniform corticothalamic continuum model of electroencephalographic spectra with application to split-alpha peaks (2003) Phys. Rev. E, 68, p. 021922; Snaedal, J., Johannesson, G.H., Gudmundsson, T.E., Blin, N.P., Emilsdottir, A.L., Einarsson, B., Johnsen, K., Diagnostic accuracy of statistical pattern recognition of electroencephalogram registration in evaluation of cognitive impairment and dementia (2012) Dement. Geriatr. Cogn., 34, pp. 51-60; Volkow, N.D., Wang, G.J., Hitzemann, R., Fowler, J.S., Pappas, N., Lowrimore, P., Burr, G., Wolf, A.P., Depression of thalamic metabolism by lorazepam is associated with sleepiness (1995) Neuropsychopharmacology, 12, pp. 123-132; Walker, M.P., Ayre, G.A., Cummings, J.L., Wesnes, K., McKeith, I.G., O'Brien, J.T., Ballard, C.G., The Clinician assessment of fluctuation and the one Day fluctuation assessment scale. Two methods to assess fluctuating confusion in dementia (2000) Br. J. Psychiatry, 177, pp. 252-256; Ward, L.M., The thalamic dynamic core theory of conscious experience (2011) Conscious Cogn., 20, pp. 464-486; World Health Organization, The ICD-10 Classification of Mental and Behavioural Disorders (1992), WHO GenevaUR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085008736&doi=10.1016%2fj.neurobiolaging.2020.04.023&partnerID=40&md5=f419f5138cb3ef03c618614c3df07e0a
PY - 2020
Y1 - 2020
N2 - Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p <0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition. © 2020 Elsevier Inc.
AB - Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p <0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition. © 2020 Elsevier Inc.
KW - Dementia with Lewy bodies
KW - EEG rhythms
KW - Thalamocortical dysfunctions
KW - aged
KW - alpha rhythm
KW - Alzheimer disease
KW - Article
KW - brain cortex
KW - cognitive defect
KW - cohort analysis
KW - controlled study
KW - delta rhythm
KW - diffuse Lewy body disease
KW - dominant frequency
KW - EEG abnormality
KW - electroencephalogram
KW - electroencephalography
KW - Europe
KW - female
KW - human
KW - major clinical study
KW - male
KW - prealpha rhythm
KW - priority journal
KW - thalamocortical dysrhythmia
KW - theta rhythm
KW - brain
KW - clinical trial
KW - cognition
KW - differential diagnosis
KW - multicenter study
KW - pathophysiology
KW - psychology
KW - very elderly
KW - Aged
KW - Aged, 80 and over
KW - Alzheimer Disease
KW - Brain
KW - Cognition
KW - Cohort Studies
KW - Diagnosis, Differential
KW - Electroencephalography
KW - Female
KW - Humans
KW - Lewy Body Disease
KW - Male
U2 - 10.1016/j.neurobiolaging.2020.04.023
DO - 10.1016/j.neurobiolaging.2020.04.023
M3 - Article
VL - 93
SP - 55
EP - 60
JO - Neurobiol. Aging
JF - Neurobiol. Aging
SN - 0197-4580
ER -