Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study

R. Franciotti, A. Pilotto, D.V. Moretti, N.W. Falasca, D. Arnaldi, J.-P. Taylor, F. Nobili, M. Kramberger, S.G. Ptacek, A. Padovani, D. Aarlsand, M. Onofrj, L. Bonanni, E-DLB consortium

Research output: Contribution to journalArticlepeer-review

Abstract

Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p <0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition. © 2020 Elsevier Inc.
Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalNeurobiol. Aging
Volume93
DOIs
Publication statusPublished - 2020

Keywords

  • Dementia with Lewy bodies
  • EEG rhythms
  • Thalamocortical dysfunctions
  • aged
  • alpha rhythm
  • Alzheimer disease
  • Article
  • brain cortex
  • cognitive defect
  • cohort analysis
  • controlled study
  • delta rhythm
  • diffuse Lewy body disease
  • dominant frequency
  • EEG abnormality
  • electroencephalogram
  • electroencephalography
  • Europe
  • female
  • human
  • major clinical study
  • male
  • prealpha rhythm
  • priority journal
  • thalamocortical dysrhythmia
  • theta rhythm
  • brain
  • clinical trial
  • cognition
  • differential diagnosis
  • multicenter study
  • pathophysiology
  • psychology
  • very elderly
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Brain
  • Cognition
  • Cohort Studies
  • Diagnosis, Differential
  • Electroencephalography
  • Female
  • Humans
  • Lewy Body Disease
  • Male

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