Anterior EEG slowing in dementia with Lewy bodies::  a multicenter European cohort study

R. Franciotti; A. Pilotto; D.V. Moretti; N.W. Falasca; D. Arnaldi; J.-P. Taylor; F. Nobili; M. Kramberger; S.G. Ptacek; A. Padovani; D. Aarlsand; M. Onofrj; L. Bonanni; E-DLB consortium

doi:10.1016/j.neurobiolaging.2020.04.023

Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study

R. Franciotti, A. Pilotto, D.V. Moretti, N.W. Falasca, D. Arnaldi, J.-P. Taylor, F. Nobili, M. Kramberger, S.G. Ptacek, A. Padovani, D. Aarlsand, M. Onofrj, L. Bonanni, E-DLB consortium

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p <0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition. © 2020 Elsevier Inc.

Original language	English
Pages (from-to)	55-60
Number of pages	6
Journal	Neurobiol. Aging
Volume	93
DOIs	https://doi.org/10.1016/j.neurobiolaging.2020.04.023
Publication status	Published - 2020

Keywords

Dementia with Lewy bodies
EEG rhythms
Thalamocortical dysfunctions
aged
alpha rhythm
Alzheimer disease
Article
brain cortex
cognitive defect
cohort analysis
controlled study
delta rhythm
diffuse Lewy body disease
dominant frequency
EEG abnormality
electroencephalogram
electroencephalography
Europe
female
human
major clinical study
male
prealpha rhythm
priority journal
thalamocortical dysrhythmia
theta rhythm
brain
clinical trial
cognition
differential diagnosis
multicenter study
pathophysiology
psychology
very elderly
Aged
Aged, 80 and over
Alzheimer Disease
Brain
Cognition
Cohort Studies
Diagnosis, Differential
Electroencephalography
Female
Humans
Lewy Body Disease
Male

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10.1016/j.neurobiolaging.2020.04.023

Cite this

Franciotti, R., Pilotto, A., Moretti, D. V., Falasca, N. W., Arnaldi, D., Taylor, J-P., Nobili, F., Kramberger, M., Ptacek, S. G., Padovani, A., Aarlsand, D., Onofrj, M., Bonanni, L., & consortium, E-DLB. (2020). Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study. Neurobiol. Aging, 93, 55-60. https://doi.org/10.1016/j.neurobiolaging.2020.04.023

Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study. / Franciotti, R.; Pilotto, A.; Moretti, D.V.; Falasca, N.W.; Arnaldi, D.; Taylor, J.-P.; Nobili, F.; Kramberger, M.; Ptacek, S.G.; Padovani, A.; Aarlsand, D.; Onofrj, M.; Bonanni, L.; consortium, E-DLB.

In: Neurobiol. Aging, Vol. 93, 2020, p. 55-60.

Research output: Contribution to journal › Article › peer-review

Franciotti, R, Pilotto, A, Moretti, DV, Falasca, NW, Arnaldi, D, Taylor, J-P, Nobili, F, Kramberger, M, Ptacek, SG, Padovani, A, Aarlsand, D, Onofrj, M, Bonanni, L & consortium, E-DLB 2020, 'Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study', Neurobiol. Aging, vol. 93, pp. 55-60. https://doi.org/10.1016/j.neurobiolaging.2020.04.023

@article{30109389a1094d39baed7aa6b1bbf54e,

title = "Anterior EEG slowing in dementia with Lewy bodies:: a multicenter European cohort study",

abstract = "Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p <0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition. {\textcopyright} 2020 Elsevier Inc.",

keywords = "Dementia with Lewy bodies, EEG rhythms, Thalamocortical dysfunctions, aged, alpha rhythm, Alzheimer disease, Article, brain cortex, cognitive defect, cohort analysis, controlled study, delta rhythm, diffuse Lewy body disease, dominant frequency, EEG abnormality, electroencephalogram, electroencephalography, Europe, female, human, major clinical study, male, prealpha rhythm, priority journal, thalamocortical dysrhythmia, theta rhythm, brain, clinical trial, cognition, differential diagnosis, multicenter study, pathophysiology, psychology, very elderly, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition, Cohort Studies, Diagnosis, Differential, Electroencephalography, Female, Humans, Lewy Body Disease, Male",

author = "R. Franciotti and A. Pilotto and D.V. Moretti and N.W. Falasca and D. Arnaldi and J.-P. Taylor and F. Nobili and M. Kramberger and S.G. Ptacek and A. Padovani and D. Aarlsand and M. Onofrj and L. Bonanni and E-DLB consortium",

note = "Cited By :3 Export Date: 23 February 2021 CODEN: NEAGD Correspondence Address: Bonanni, L.; Department of Neuroscience, Via dei Vestini, Italy; email: l.bonanni@unich.it Funding details: National Institute for Health Research, NIHR Funding details: South London and Maudsley NHS Foundation Trust Funding details: King{\textquoteright}s College London Funding text 1: This paper represents independent research partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King{\textquoteright}s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. References: Antelmi, E., Ferri, R., Iranzo, A., Arnulf, I., Dauvilliers, Y., Bhatia, K.P., Liguori, R., Plazzi, G., From state dissociation to status dissociatus (2016) Sleep Med. Rev., 28, pp. 5-17; Bonanni, L., Franciotti, R., Nobili, F., Kramberger, M.G., Taylor, J.P., Garcia-Ptacek, S., Falasca, N.W., Aarsland, D., EEG Markers of dementia with Lewy bodies: a multicenter cohort study (2016) J. Alzheimers Dis., 54, pp. 1649-1657; Bonanni, L., Perfetti, B., Bifolchetti, S., Taylor, J.P., Franciotti, R., Parnetti, L., Thomas, A., Onofrj, M., Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies (2015) Neurobiol. Aging, 36, pp. 434-445; Bonanni, L., Thomas, A., Tiraboschi, P., Perfetti, B., Varanese, S., Onofrj, M., EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up (2008) Brain, 131, pp. 690-705; Caviness, J.N., Hentz, J.G., Evidente, V.G., Driver-Dunckley, E., Samanta, J., Mahant, P., Connor, D.J., Adler, C.H., Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease (2007) Parkinsonism Relat. Disord., 13, pp. 348-354; Chiang, A.K., Rennie, C.J., Robinson, P.A., Roberts, J.A., Rigozzi, M.K., Whitehouse, R.W., Hamilton, R.J., Gordon, E., Automated characterization of multiple alpha peaks in multi-site electroencephalograms (2008) J. Neurosci. Meth., 168, pp. 396-411; Cozac, V.V., Gschwandtner, U., Hatz, F., Hardmeier, M., R{\"u}egg, S., Fuhr, P., Quantitative EEG and cognitive Decline in Parkinson's disease (2016) Parkinsons Dis., p. 9060649; Cummings, J.L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D.A., Gornbein, J., The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia (1994) Neurology, 44, pp. 2308-2314; Delli Pizzi, S., Franciotti, R., Taylor, J.P., Esposito, R., Tartaro, A., Thomas, A., Onofrj, M., Bonanni, L., Structural connectivity is differently altered in dementia with Lewy body and Alzheimer's disease (2015) Front. Aging Neurosci., 7, p. 208; Delli Pizzi, S., Franciotti, R., Taylor, J.P., Thomas, A., Tartaro, A., Onofrj, M., Bonanni, L., Thalamic Involvement in fluctuating cognition in dementia with Lewy bodies: Magnetic Resonance Evidences (2015) Cereb. Cortex, 25, pp. 3682-3689; Delli Pizzi, S., Maruotti, V., Taylor, J.P., Franciotti, R., Caulo, M., Tartaro, A., Thomas, A., Bonanni, L., Relevance of subcortical visual pathways disruption to visual symptoms in dementia with Lewy bodies (2014) Cortex, 59, pp. 12-21; Fiset, P., Paus, T., Daloze, T., Plourde, G., Meuret, P., Bonhomme, V., Hajj-Ali, N., Evans, A.C., Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study (1999) J. Neurosci., 19, pp. 5506-5513; Foucher, J.R., Otzenberger, H., Gounot, D., Where arousal meets attention: a simultaneous fMRI and EEG recording study (2004) Neuroimage, 22, pp. 688-697; Garn, H., Coronel, C., Waser, M., Caravias, G., Ransmayr, G., Differential diagnosis between patients with probable Alzheimer's disease, Parkinson's disease dementia, or dementia with Lewy bodies and frontotemporal dementia, behavioral variant, using quantitative electroencephalographic features (2017) J. Neural Transm., 124, pp. 569-581; Kenny, E.R., O'Brien, J.T., Firbank, M.J., Blamire, A.M., Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease (2013) Br. J. Psychiatry, 203, pp. 209-214; Llin{\'a}s, R.R., Ribary, U., Jeanmonod, D., Kronberg, E., Mitra, P.P., Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography (1999) Proc. Natl. Acad. Sci. U. S. A., 96, pp. 15222-15227; Llin{\'a}s, R.R., Steriade, M., Bursting of thalamic neurons and states of vigilance (2006) J. Neurophysiol., 95, pp. 3297-3308; McKeith, I.G., Boeve, B.F., Dickson, D.W., Halliday, G., Taylor, J.P., Weintraub, D., Aarsland, D., Kosaka, K., Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium (2017) Neurology, 89, pp. 88-100; McKeith, I.G., Dickson, D.W., Lowe, J., Emre, M., O'Brien, J.T., Feldman, H., Cummings, J., Consortium on DLB, Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium (2005) Neurology, 65, pp. 1863-1872; McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R., Jr., Kawas, C.H., Klunk, W.E., Phelps, C.H., The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease (2011) Alzheimers Dement., 7, pp. 263-269; Niedermeyer, E., Lopes Da Silva, F.H., Electroencephalography: Basic Principles, Clinical Applications, and Related Fields (2005), Lippincott and Williams Baltimore, Maryland; Onofrj, M., Thomas, A., Iacono, D., Luciano, A.L., Di Iorio, A., The effects of a cholinesterase inhibitor are prominent in patients with fluctuating cognition: a part 3 study of the main mechanism of cholinesterase inhibitors in dementia (2003) Clin. Neuropharmacol., 26, pp. 239-251; Perry, E., Walker, M., Grace, J., Perry, R., Acetylcholine in mind: a neurotransmitter correlate of consciousness? (1999) Trends Neurosci., 22, pp. 273-280; Pilotto, A., Schiano di Cola, F., Premi, E., Grasso, R., Turrone, R., Gipponi, S., Scalvini, A., Padovani, A., Extrastriatal dopaminergic and serotonergic pathways in Parkinson's disease and in dementia with Lewy bodies: a 123I-FP-CIT SPECT study (2019) Eur. J. Nucl. Med. Mol. Imaging, 46, pp. 1642-1651; Robinson, P.A., Whitehouse, R.W., Rennie, C.J., Nonuniform corticothalamic continuum model of electroencephalographic spectra with application to split-alpha peaks (2003) Phys. Rev. E, 68, p. 021922; Snaedal, J., Johannesson, G.H., Gudmundsson, T.E., Blin, N.P., Emilsdottir, A.L., Einarsson, B., Johnsen, K., Diagnostic accuracy of statistical pattern recognition of electroencephalogram registration in evaluation of cognitive impairment and dementia (2012) Dement. Geriatr. Cogn., 34, pp. 51-60; Volkow, N.D., Wang, G.J., Hitzemann, R., Fowler, J.S., Pappas, N., Lowrimore, P., Burr, G., Wolf, A.P., Depression of thalamic metabolism by lorazepam is associated with sleepiness (1995) Neuropsychopharmacology, 12, pp. 123-132; Walker, M.P., Ayre, G.A., Cummings, J.L., Wesnes, K., McKeith, I.G., O'Brien, J.T., Ballard, C.G., The Clinician assessment of fluctuation and the one Day fluctuation assessment scale. Two methods to assess fluctuating confusion in dementia (2000) Br. J. Psychiatry, 177, pp. 252-256; Ward, L.M., The thalamic dynamic core theory of conscious experience (2011) Conscious Cogn., 20, pp. 464-486; World Health Organization, The ICD-10 Classification of Mental and Behavioural Disorders (1992), WHO GenevaUR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085008736&doi=10.1016%2fj.neurobiolaging.2020.04.023&partnerID=40&md5=f419f5138cb3ef03c618614c3df07e0a",

year = "2020",

doi = "10.1016/j.neurobiolaging.2020.04.023",

language = "English",

volume = "93",

pages = "55--60",

journal = "Neurobiol. Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Anterior EEG slowing in dementia with Lewy bodies:

T2 - a multicenter European cohort study

AU - Franciotti, R.

AU - Pilotto, A.

AU - Moretti, D.V.

AU - Falasca, N.W.

AU - Arnaldi, D.

AU - Taylor, J.-P.

AU - Nobili, F.

AU - Kramberger, M.

AU - Ptacek, S.G.

AU - Padovani, A.

AU - Aarlsand, D.

AU - Onofrj, M.

AU - Bonanni, L.

AU - consortium, E-DLB

N1 - Cited By :3 Export Date: 23 February 2021 CODEN: NEAGD Correspondence Address: Bonanni, L.; Department of Neuroscience, Via dei Vestini, Italy; email: l.bonanni@unich.it Funding details: National Institute for Health Research, NIHR Funding details: South London and Maudsley NHS Foundation Trust Funding details: King’s College London Funding text 1: This paper represents independent research partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. References: Antelmi, E., Ferri, R., Iranzo, A., Arnulf, I., Dauvilliers, Y., Bhatia, K.P., Liguori, R., Plazzi, G., From state dissociation to status dissociatus (2016) Sleep Med. Rev., 28, pp. 5-17; Bonanni, L., Franciotti, R., Nobili, F., Kramberger, M.G., Taylor, J.P., Garcia-Ptacek, S., Falasca, N.W., Aarsland, D., EEG Markers of dementia with Lewy bodies: a multicenter cohort study (2016) J. Alzheimers Dis., 54, pp. 1649-1657; Bonanni, L., Perfetti, B., Bifolchetti, S., Taylor, J.P., Franciotti, R., Parnetti, L., Thomas, A., Onofrj, M., Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies (2015) Neurobiol. Aging, 36, pp. 434-445; Bonanni, L., Thomas, A., Tiraboschi, P., Perfetti, B., Varanese, S., Onofrj, M., EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up (2008) Brain, 131, pp. 690-705; Caviness, J.N., Hentz, J.G., Evidente, V.G., Driver-Dunckley, E., Samanta, J., Mahant, P., Connor, D.J., Adler, C.H., Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease (2007) Parkinsonism Relat. Disord., 13, pp. 348-354; Chiang, A.K., Rennie, C.J., Robinson, P.A., Roberts, J.A., Rigozzi, M.K., Whitehouse, R.W., Hamilton, R.J., Gordon, E., Automated characterization of multiple alpha peaks in multi-site electroencephalograms (2008) J. Neurosci. Meth., 168, pp. 396-411; Cozac, V.V., Gschwandtner, U., Hatz, F., Hardmeier, M., Rüegg, S., Fuhr, P., Quantitative EEG and cognitive Decline in Parkinson's disease (2016) Parkinsons Dis., p. 9060649; Cummings, J.L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D.A., Gornbein, J., The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia (1994) Neurology, 44, pp. 2308-2314; Delli Pizzi, S., Franciotti, R., Taylor, J.P., Esposito, R., Tartaro, A., Thomas, A., Onofrj, M., Bonanni, L., Structural connectivity is differently altered in dementia with Lewy body and Alzheimer's disease (2015) Front. Aging Neurosci., 7, p. 208; Delli Pizzi, S., Franciotti, R., Taylor, J.P., Thomas, A., Tartaro, A., Onofrj, M., Bonanni, L., Thalamic Involvement in fluctuating cognition in dementia with Lewy bodies: Magnetic Resonance Evidences (2015) Cereb. Cortex, 25, pp. 3682-3689; Delli Pizzi, S., Maruotti, V., Taylor, J.P., Franciotti, R., Caulo, M., Tartaro, A., Thomas, A., Bonanni, L., Relevance of subcortical visual pathways disruption to visual symptoms in dementia with Lewy bodies (2014) Cortex, 59, pp. 12-21; Fiset, P., Paus, T., Daloze, T., Plourde, G., Meuret, P., Bonhomme, V., Hajj-Ali, N., Evans, A.C., Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study (1999) J. Neurosci., 19, pp. 5506-5513; Foucher, J.R., Otzenberger, H., Gounot, D., Where arousal meets attention: a simultaneous fMRI and EEG recording study (2004) Neuroimage, 22, pp. 688-697; Garn, H., Coronel, C., Waser, M., Caravias, G., Ransmayr, G., Differential diagnosis between patients with probable Alzheimer's disease, Parkinson's disease dementia, or dementia with Lewy bodies and frontotemporal dementia, behavioral variant, using quantitative electroencephalographic features (2017) J. Neural Transm., 124, pp. 569-581; Kenny, E.R., O'Brien, J.T., Firbank, M.J., Blamire, A.M., Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease (2013) Br. J. Psychiatry, 203, pp. 209-214; Llinás, R.R., Ribary, U., Jeanmonod, D., Kronberg, E., Mitra, P.P., Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography (1999) Proc. Natl. Acad. Sci. U. S. A., 96, pp. 15222-15227; Llinás, R.R., Steriade, M., Bursting of thalamic neurons and states of vigilance (2006) J. Neurophysiol., 95, pp. 3297-3308; McKeith, I.G., Boeve, B.F., Dickson, D.W., Halliday, G., Taylor, J.P., Weintraub, D., Aarsland, D., Kosaka, K., Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium (2017) Neurology, 89, pp. 88-100; McKeith, I.G., Dickson, D.W., Lowe, J., Emre, M., O'Brien, J.T., Feldman, H., Cummings, J., Consortium on DLB, Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium (2005) Neurology, 65, pp. 1863-1872; McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R., Jr., Kawas, C.H., Klunk, W.E., Phelps, C.H., The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease (2011) Alzheimers Dement., 7, pp. 263-269; Niedermeyer, E., Lopes Da Silva, F.H., Electroencephalography: Basic Principles, Clinical Applications, and Related Fields (2005), Lippincott and Williams Baltimore, Maryland; Onofrj, M., Thomas, A., Iacono, D., Luciano, A.L., Di Iorio, A., The effects of a cholinesterase inhibitor are prominent in patients with fluctuating cognition: a part 3 study of the main mechanism of cholinesterase inhibitors in dementia (2003) Clin. Neuropharmacol., 26, pp. 239-251; Perry, E., Walker, M., Grace, J., Perry, R., Acetylcholine in mind: a neurotransmitter correlate of consciousness? (1999) Trends Neurosci., 22, pp. 273-280; Pilotto, A., Schiano di Cola, F., Premi, E., Grasso, R., Turrone, R., Gipponi, S., Scalvini, A., Padovani, A., Extrastriatal dopaminergic and serotonergic pathways in Parkinson's disease and in dementia with Lewy bodies: a 123I-FP-CIT SPECT study (2019) Eur. J. Nucl. Med. Mol. Imaging, 46, pp. 1642-1651; Robinson, P.A., Whitehouse, R.W., Rennie, C.J., Nonuniform corticothalamic continuum model of electroencephalographic spectra with application to split-alpha peaks (2003) Phys. Rev. E, 68, p. 021922; Snaedal, J., Johannesson, G.H., Gudmundsson, T.E., Blin, N.P., Emilsdottir, A.L., Einarsson, B., Johnsen, K., Diagnostic accuracy of statistical pattern recognition of electroencephalogram registration in evaluation of cognitive impairment and dementia (2012) Dement. Geriatr. Cogn., 34, pp. 51-60; Volkow, N.D., Wang, G.J., Hitzemann, R., Fowler, J.S., Pappas, N., Lowrimore, P., Burr, G., Wolf, A.P., Depression of thalamic metabolism by lorazepam is associated with sleepiness (1995) Neuropsychopharmacology, 12, pp. 123-132; Walker, M.P., Ayre, G.A., Cummings, J.L., Wesnes, K., McKeith, I.G., O'Brien, J.T., Ballard, C.G., The Clinician assessment of fluctuation and the one Day fluctuation assessment scale. Two methods to assess fluctuating confusion in dementia (2000) Br. J. Psychiatry, 177, pp. 252-256; Ward, L.M., The thalamic dynamic core theory of conscious experience (2011) Conscious Cogn., 20, pp. 464-486; World Health Organization, The ICD-10 Classification of Mental and Behavioural Disorders (1992), WHO GenevaUR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085008736&doi=10.1016%2fj.neurobiolaging.2020.04.023&partnerID=40&md5=f419f5138cb3ef03c618614c3df07e0a

PY - 2020

Y1 - 2020

N2 - Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p <0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition. © 2020 Elsevier Inc.

AB - Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p <0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition. © 2020 Elsevier Inc.

KW - Dementia with Lewy bodies

KW - EEG rhythms

KW - Thalamocortical dysfunctions

KW - aged

KW - alpha rhythm

KW - Alzheimer disease

KW - Article

KW - brain cortex

KW - cognitive defect

KW - cohort analysis

KW - controlled study

KW - delta rhythm

KW - diffuse Lewy body disease

KW - dominant frequency

KW - EEG abnormality

KW - electroencephalogram

KW - electroencephalography

KW - Europe

KW - female

KW - human

KW - major clinical study

KW - male

KW - prealpha rhythm

KW - priority journal

KW - thalamocortical dysrhythmia

KW - theta rhythm

KW - brain

KW - clinical trial

KW - cognition

KW - differential diagnosis

KW - multicenter study

KW - pathophysiology

KW - psychology

KW - very elderly

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Brain

KW - Cognition

KW - Cohort Studies

KW - Diagnosis, Differential

KW - Electroencephalography

KW - Female

KW - Humans

KW - Lewy Body Disease

KW - Male

U2 - 10.1016/j.neurobiolaging.2020.04.023

DO - 10.1016/j.neurobiolaging.2020.04.023

M3 - Article

VL - 93

SP - 55

EP - 60

JO - Neurobiol. Aging

JF - Neurobiol. Aging

SN - 0197-4580

ER -

Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study

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