Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Julie A. Britton, Aneire E. Khan, Sabine Rohrmann, Nikolaus Becker, Jakob Linseisen, Alexandra Nieters, Rudolf Kaaks, Anne Tjønneland, Jytte Halkjær, Marianne Tang Severinsen, Kim Overvad, Tobias Pischon, Heiner Boeing, Antonia Trichopoulou, Victoria Kalapothaki, Dimitrios Trichopoulos, Amalia Mattiello, Giovanna Tagliabue, Carlotta Sacerdote, Petra H M PeetersH. Bas Bueno-de-Mesquita, Eva Ardanaz, Carmen Navarro, Paula Jakszyn, Jone M. Altzibar, Göran Hallmans, Beatrice Malmer, Göran Berglund, Jonas Manjer, Naomi Allen, Timothy Key, Sheila Bingham, Hervé Besson, Pietro Ferrari, Mazda Jenab, Paolo Boffetta, Paolo Vineis, Elio Riboli

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. Design and Methods: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. Results: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend <0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). Conclusions: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.

Original languageEnglish
Pages (from-to)1666-1677
Number of pages12
JournalHaematologica
Volume93
Issue number11
DOIs
Publication statusPublished - Nov 2008

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Multiple Myeloma
Non-Hodgkin's Lymphoma
Confidence Intervals
Neoplasms
Body Mass Index
Follicular Lymphoma
Obesity
Abdominal Fat
Waist-Hip Ratio
Lymphoma, Large B-Cell, Diffuse
Adiposity
Proportional Hazards Models
Hip
Prospective Studies
Weights and Measures
Incidence

Keywords

  • Anthropometry
  • Cohort study
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Britton, Julie A.; Khan, Aneire E.; Rohrmann, Sabine; Becker, Nikolaus; Linseisen, Jakob; Nieters, Alexandra; Kaaks, Rudolf; Tjønneland, Anne; Halkjær, Jytte; Severinsen, Marianne Tang; Overvad, Kim; Pischon, Tobias; Boeing, Heiner; Trichopoulou, Antonia; Kalapothaki, Victoria; Trichopoulos, Dimitrios; Mattiello, Amalia; Tagliabue, Giovanna; Sacerdote, Carlotta; Peeters, Petra H M; Bueno-de-Mesquita, H. Bas; Ardanaz, Eva; Navarro, Carmen; Jakszyn, Paula; Altzibar, Jone M.; Hallmans, Göran; Malmer, Beatrice; Berglund, Göran; Manjer, Jonas; Allen, Naomi; Key, Timothy; Bingham, Sheila; Besson, Hervé; Ferrari, Pietro; Jenab, Mazda; Boffetta, Paolo; Vineis, Paolo; Riboli, Elio.

In: Haematologica, Vol. 93, No. 11, 11.2008, p. 1666-1677.

Research output: Contribution to journalArticle

Britton, JA, Khan, AE, Rohrmann, S, Becker, N, Linseisen, J, Nieters, A, Kaaks, R, Tjønneland, A, Halkjær, J, Severinsen, MT, Overvad, K, Pischon, T, Boeing, H, Trichopoulou, A, Kalapothaki, V, Trichopoulos, D, Mattiello, A, Tagliabue, G, Sacerdote, C, Peeters, PHM, Bueno-de-Mesquita, HB, Ardanaz, E, Navarro, C, Jakszyn, P, Altzibar, JM, Hallmans, G, Malmer, B, Berglund, G, Manjer, J, Allen, N, Key, T, Bingham, S, Besson, H, Ferrari, P, Jenab, M, Boffetta, P, Vineis, P & Riboli, E 2008, 'Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)', Haematologica, vol. 93, no. 11, pp. 1666-1677. https://doi.org/10.3324/haematol.13078
Britton, Julie A. ; Khan, Aneire E. ; Rohrmann, Sabine ; Becker, Nikolaus ; Linseisen, Jakob ; Nieters, Alexandra ; Kaaks, Rudolf ; Tjønneland, Anne ; Halkjær, Jytte ; Severinsen, Marianne Tang ; Overvad, Kim ; Pischon, Tobias ; Boeing, Heiner ; Trichopoulou, Antonia ; Kalapothaki, Victoria ; Trichopoulos, Dimitrios ; Mattiello, Amalia ; Tagliabue, Giovanna ; Sacerdote, Carlotta ; Peeters, Petra H M ; Bueno-de-Mesquita, H. Bas ; Ardanaz, Eva ; Navarro, Carmen ; Jakszyn, Paula ; Altzibar, Jone M. ; Hallmans, Göran ; Malmer, Beatrice ; Berglund, Göran ; Manjer, Jonas ; Allen, Naomi ; Key, Timothy ; Bingham, Sheila ; Besson, Hervé ; Ferrari, Pietro ; Jenab, Mazda ; Boffetta, Paolo ; Vineis, Paolo ; Riboli, Elio. / Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). In: Haematologica. 2008 ; Vol. 93, No. 11. pp. 1666-1677.
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abstract = "Background: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. Design and Methods: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95{\%} confidence intervals (95{\%} CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. Results: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95{\%} CI 1.14-1.98) for highest versus lowest quartile; p-trend <0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95{\%} CI 0.85-1.38) and 0.92 (95{\%} CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95{\%} CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95{\%} CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95{\%} CI 1.29-4.21) and heavier men (RR 1.77, 95{\%} CI 1.02-3.05). Conclusions: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.",
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journal = "Haematologica",
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TY - JOUR

T1 - Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Britton, Julie A.

AU - Khan, Aneire E.

AU - Rohrmann, Sabine

AU - Becker, Nikolaus

AU - Linseisen, Jakob

AU - Nieters, Alexandra

AU - Kaaks, Rudolf

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Severinsen, Marianne Tang

AU - Overvad, Kim

AU - Pischon, Tobias

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Kalapothaki, Victoria

AU - Trichopoulos, Dimitrios

AU - Mattiello, Amalia

AU - Tagliabue, Giovanna

AU - Sacerdote, Carlotta

AU - Peeters, Petra H M

AU - Bueno-de-Mesquita, H. Bas

AU - Ardanaz, Eva

AU - Navarro, Carmen

AU - Jakszyn, Paula

AU - Altzibar, Jone M.

AU - Hallmans, Göran

AU - Malmer, Beatrice

AU - Berglund, Göran

AU - Manjer, Jonas

AU - Allen, Naomi

AU - Key, Timothy

AU - Bingham, Sheila

AU - Besson, Hervé

AU - Ferrari, Pietro

AU - Jenab, Mazda

AU - Boffetta, Paolo

AU - Vineis, Paolo

AU - Riboli, Elio

PY - 2008/11

Y1 - 2008/11

N2 - Background: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. Design and Methods: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. Results: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend <0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). Conclusions: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.

AB - Background: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. Design and Methods: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. Results: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend <0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). Conclusions: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.

KW - Anthropometry

KW - Cohort study

KW - Non-Hodgkin's lymphoma

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