Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Fatemeh Saberi Hosnijeh, Isabelle Romieu, Valentina Gallo, Elio Riboli, Anne Tjønneland, Jytte Halkjær, Guy Fagherazzi, Françoise Clavel-Chapelon, Laure Dossus, Annie Lukanova, Rudolf Kaaks, Antonia Trichopoulou, Pagona Lagiou, Michael Katsoulis, Salvatore Panico, Giovanna Tagliabue, Catalina Bonet, Miren Dorronsoro, José María Huerta, Eva ArdanazMaria José Sánchez, Dorthe Johansen, Signe Borgquist, Petra Peeters, H. Bas Bueno-De-Mesquita, Martine M. Ros, Ruth C. Travis, Timothy J. Key, Paolo Vineis, Roel Vermeulen

Research output: Contribution to journalArticle

Abstract

Purpose: Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia. Results: No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height. Conclusion: The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed.

Original languageEnglish
Pages (from-to)427-438
Number of pages12
JournalCancer Causes and Control
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 2013

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Lymphoid Leukemia
Myeloid Leukemia
Leukemia
Waist Circumference
Neoplasms
Body Mass Index
Waist-Hip Ratio
Obesity
Acute Myeloid Leukemia
Abdominal Obesity
Body Size
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leptin
Insulin-Like Growth Factor I
Proportional Hazards Models
Hip
Epidemiologic Studies
Weights and Measures

Keywords

  • Anthropometry
  • Body mass index
  • Cohort studies
  • Leukemia
  • Lymphoid
  • Myeloid

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Saberi Hosnijeh, Fatemeh; Romieu, Isabelle; Gallo, Valentina; Riboli, Elio; Tjønneland, Anne; Halkjær, Jytte; Fagherazzi, Guy; Clavel-Chapelon, Françoise; Dossus, Laure; Lukanova, Annie; Kaaks, Rudolf; Trichopoulou, Antonia; Lagiou, Pagona; Katsoulis, Michael; Panico, Salvatore; Tagliabue, Giovanna; Bonet, Catalina; Dorronsoro, Miren; Huerta, José María; Ardanaz, Eva; Sánchez, Maria José; Johansen, Dorthe; Borgquist, Signe; Peeters, Petra; Bueno-De-Mesquita, H. Bas; Ros, Martine M.; Travis, Ruth C.; Key, Timothy J.; Vineis, Paolo; Vermeulen, Roel.

In: Cancer Causes and Control, Vol. 24, No. 3, 03.2013, p. 427-438.

Research output: Contribution to journalArticle

Saberi Hosnijeh, F, Romieu, I, Gallo, V, Riboli, E, Tjønneland, A, Halkjær, J, Fagherazzi, G, Clavel-Chapelon, F, Dossus, L, Lukanova, A, Kaaks, R, Trichopoulou, A, Lagiou, P, Katsoulis, M, Panico, S, Tagliabue, G, Bonet, C, Dorronsoro, M, Huerta, JM, Ardanaz, E, Sánchez, MJ, Johansen, D, Borgquist, S, Peeters, P, Bueno-De-Mesquita, HB, Ros, MM, Travis, RC, Key, TJ, Vineis, P & Vermeulen, R 2013, 'Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)', Cancer Causes and Control, vol. 24, no. 3, pp. 427-438. https://doi.org/10.1007/s10552-012-0128-2
Saberi Hosnijeh, Fatemeh ; Romieu, Isabelle ; Gallo, Valentina ; Riboli, Elio ; Tjønneland, Anne ; Halkjær, Jytte ; Fagherazzi, Guy ; Clavel-Chapelon, Françoise ; Dossus, Laure ; Lukanova, Annie ; Kaaks, Rudolf ; Trichopoulou, Antonia ; Lagiou, Pagona ; Katsoulis, Michael ; Panico, Salvatore ; Tagliabue, Giovanna ; Bonet, Catalina ; Dorronsoro, Miren ; Huerta, José María ; Ardanaz, Eva ; Sánchez, Maria José ; Johansen, Dorthe ; Borgquist, Signe ; Peeters, Petra ; Bueno-De-Mesquita, H. Bas ; Ros, Martine M. ; Travis, Ruth C. ; Key, Timothy J. ; Vineis, Paolo ; Vermeulen, Roel. / Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC). In: Cancer Causes and Control. 2013 ; Vol. 24, No. 3. pp. 427-438.
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abstract = "Purpose: Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 {\%}, myeloid leukemia = 43.2 {\%}) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia. Results: No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height. Conclusion: The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed.",
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T1 - Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Saberi Hosnijeh, Fatemeh

AU - Romieu, Isabelle

AU - Gallo, Valentina

AU - Riboli, Elio

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Fagherazzi, Guy

AU - Clavel-Chapelon, Françoise

AU - Dossus, Laure

AU - Lukanova, Annie

AU - Kaaks, Rudolf

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Katsoulis, Michael

AU - Panico, Salvatore

AU - Tagliabue, Giovanna

AU - Bonet, Catalina

AU - Dorronsoro, Miren

AU - Huerta, José María

AU - Ardanaz, Eva

AU - Sánchez, Maria José

AU - Johansen, Dorthe

AU - Borgquist, Signe

AU - Peeters, Petra

AU - Bueno-De-Mesquita, H. Bas

AU - Ros, Martine M.

AU - Travis, Ruth C.

AU - Key, Timothy J.

AU - Vineis, Paolo

AU - Vermeulen, Roel

PY - 2013/3

Y1 - 2013/3

N2 - Purpose: Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia. Results: No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height. Conclusion: The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed.

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KW - Cohort studies

KW - Leukemia

KW - Lymphoid

KW - Myeloid

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