Anthropometric characteristics of newborns with Prader-Willi syndrome

Alessandro Salvatoni; Alex Moretti; Graziano Grugni; Massimo Agosti; Sara Azzolini; Valentina Bonaita; Paola Cianci; Domenico Corica; Antonino Crinò; Maurizio Delvecchio; Silvio Ferraris; Nella A. Greggio; Lorenzo Iughetti; Maria R. Licenziati; Simona F. Madeo; Luana Nosetti; Roberta Pajno; Irene Rutigliano; Michele Sacco; Silvia Salvatore; Emanuela Scarano; Giuliana Trifirò; Malgorzata Wasniewska

doi:10.1002/ajmg.a.61304

Anthropometric characteristics of newborns with Prader-Willi syndrome

Alessandro Salvatoni, Alex Moretti, Graziano Grugni, Massimo Agosti, Sara Azzolini, Valentina Bonaita, Paola Cianci, Domenico Corica, Antonino Crinò, Maurizio Delvecchio, Silvio Ferraris, Nella A. Greggio, Lorenzo Iughetti, Maria R. Licenziati, Simona F. Madeo, Luana Nosetti, Roberta Pajno, Irene Rutigliano, Michele Sacco, Silvia SalvatoreEmanuela Scarano, Giuliana Trifirò, Malgorzata Wasniewska

Research output: Contribution to journal › Article › peer-review

Abstract

This is a retrospective multicenter nationwide Italian study collecting neonatal anthropometric data of Caucasian subjects with Prader-Willi syndrome (PWS) born from 1988 to 2018. The aim of the study is to provide percentile charts for weight and length of singletons with PWS born between 36 and 42 gestational weeks. We collected the birth weight and birth length of 252 male and 244 female singleton live born infants with both parents of Italian origin and PWS genetically confirmed. Percentile smoothed curves of birth weight and length for gestational age were built through Cole's lambda, mu, sigma method. The data were compared to normal Italian standards. Newborns with PWS showed a lower mean birth weight, by 1/2 kg, and a shorter mean birth length, by 1 cm, than healthy neonates. Females with a 15q11-13 deletion were shorter than those with maternal uniparental maternal disomy of chromosome 15 (pâ€‰

Original language	English
Pages (from-to)	2067-2074
Number of pages	8
Journal	American Journal of Medical Genetics, Part A
Volume	179
Issue number	10
DOIs	https://doi.org/10.1002/ajmg.a.61304
Publication status	Published - Oct 1 2019

Keywords

growth
newborn
percentiles
Prader-Willi

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Salvatoni, A., Moretti, A., Grugni, G., Agosti, M., Azzolini, S., Bonaita, V., Cianci, P., Corica, D., Crinò, A., Delvecchio, M., Ferraris, S., Greggio, N. A., Iughetti, L., Licenziati, M. R., Madeo, S. F., Nosetti, L., Pajno, R., Rutigliano, I., Sacco, M., ... Wasniewska, M. (2019). Anthropometric characteristics of newborns with Prader-Willi syndrome. American Journal of Medical Genetics, Part A, 179(10), 2067-2074. https://doi.org/10.1002/ajmg.a.61304

Salvatoni, A, Moretti, A, Grugni, G, Agosti, M, Azzolini, S, Bonaita, V, Cianci, P, Corica, D, Crinò, A, Delvecchio, M, Ferraris, S, Greggio, NA, Iughetti, L, Licenziati, MR, Madeo, SF, Nosetti, L, Pajno, R, Rutigliano, I, Sacco, M, Salvatore, S, Scarano, E, Trifirò, G & Wasniewska, M 2019, 'Anthropometric characteristics of newborns with Prader-Willi syndrome', American Journal of Medical Genetics, Part A, vol. 179, no. 10, pp. 2067-2074. https://doi.org/10.1002/ajmg.a.61304

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title = "Anthropometric characteristics of newborns with Prader-Willi syndrome",

abstract = "This is a retrospective multicenter nationwide Italian study collecting neonatal anthropometric data of Caucasian subjects with Prader-Willi syndrome (PWS) born from 1988 to 2018. The aim of the study is to provide percentile charts for weight and length of singletons with PWS born between 36 and 42 gestational weeks. We collected the birth weight and birth length of 252 male and 244 female singleton live born infants with both parents of Italian origin and PWS genetically confirmed. Percentile smoothed curves of birth weight and length for gestational age were built through Cole's lambda, mu, sigma method. The data were compared to normal Italian standards. Newborns with PWS showed a lower mean birth weight, by 1/2 kg, and a shorter mean birth length, by 1 cm, than healthy neonates. Females with a 15q11-13 deletion were shorter than those with maternal uniparental maternal disomy of chromosome 15 (p{\^a}€‰",

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author = "Alessandro Salvatoni and Alex Moretti and Graziano Grugni and Massimo Agosti and Sara Azzolini and Valentina Bonaita and Paola Cianci and Domenico Corica and Antonino Crin{\`o} and Maurizio Delvecchio and Silvio Ferraris and Greggio, {Nella A.} and Lorenzo Iughetti and Licenziati, {Maria R.} and Madeo, {Simona F.} and Luana Nosetti and Roberta Pajno and Irene Rutigliano and Michele Sacco and Silvia Salvatore and Emanuela Scarano and Giuliana Trifir{\`o} and Malgorzata Wasniewska",

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AU - Salvatoni, Alessandro

AU - Moretti, Alex

AU - Grugni, Graziano

AU - Agosti, Massimo

AU - Azzolini, Sara

AU - Bonaita, Valentina

AU - Cianci, Paola

AU - Corica, Domenico

AU - Crinò, Antonino

AU - Delvecchio, Maurizio

AU - Ferraris, Silvio

AU - Greggio, Nella A.

AU - Iughetti, Lorenzo

AU - Licenziati, Maria R.

AU - Madeo, Simona F.

AU - Nosetti, Luana

AU - Pajno, Roberta

AU - Rutigliano, Irene

AU - Sacco, Michele

AU - Salvatore, Silvia

AU - Scarano, Emanuela

AU - Trifirò, Giuliana

AU - Wasniewska, Malgorzata

PY - 2019/10/1

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AB - This is a retrospective multicenter nationwide Italian study collecting neonatal anthropometric data of Caucasian subjects with Prader-Willi syndrome (PWS) born from 1988 to 2018. The aim of the study is to provide percentile charts for weight and length of singletons with PWS born between 36 and 42 gestational weeks. We collected the birth weight and birth length of 252 male and 244 female singleton live born infants with both parents of Italian origin and PWS genetically confirmed. Percentile smoothed curves of birth weight and length for gestational age were built through Cole's lambda, mu, sigma method. The data were compared to normal Italian standards. Newborns with PWS showed a lower mean birth weight, by 1/2 kg, and a shorter mean birth length, by 1 cm, than healthy neonates. Females with a 15q11-13 deletion were shorter than those with maternal uniparental maternal disomy of chromosome 15 (pâ€‰

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JF - American Journal of Medical Genetics, Part A

SN - 1552-4825

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Anthropometric characteristics of newborns with Prader-Willi syndrome

Abstract

Keywords

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