Anthropometric factors and risk of endometrial cancer: The European prospective investigation into cancer and nutrition

Christine Friedenreich, Anne Cust, Petra H. Lahmann, Karen Steindorf, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Sylvie Mesrine, Jakob Linseisen, Sabine Rohrmann, Heiner Boeing, Tobias Pischon, Anne Tjønneland, Jytte Halkjær, Kim Overvad, Michelle Mendez, M. L. Redondo, Carmen Martinez Garcia, Nerea Larrañaga, María José Tormo, Aurelio Barricarte GurreaSheila Bingham, Kay Tee Khaw, Naomi Allen, Tim Key, Antonia Trichopoulou, Effie Vasilopoulou, Dimitrios Trichopoulos, Valeria Pala, Domenico Palli, Rosario Tumino, Amalia Mattiello, Paolo Vineis, H. Bas Bueno-de-Mesquita, Petra H M Peeters, Göran Berglund, Jonas Manjer, Eva Lundin, Annekatrin Lukanova, Nadia Slimani, Mazda Jenab, Rudolf Kaaks, Elio Riboli

Research output: Contribution to journalArticlepeer-review


Objective: To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups. Methods: Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling. Results: Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- <40 kg/m2) compared to normal weight (BMI <25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI ≥ 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of ≥88 cm vs.

Original languageEnglish
Pages (from-to)399-413
Number of pages15
JournalCancer Causes and Control
Issue number4
Publication statusPublished - May 2007


  • Adiposity
  • Anthropometry
  • Endometrial cancer
  • Etiology
  • Hormone replacement therapy
  • Mechanisms
  • Obesity
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research


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