Anthropometric, hormonal and biochemical differences in lean and obese women before and after menopause

A. Tufano, P. Marzo, R. Enrini, L. Morricone, F. Caviezel, Bruno Ambrosi

Research output: Contribution to journalArticlepeer-review

Abstract

The menopausal status is associated with an increased risk of metabolic and cardiovascular diseases. Since the post-menopausal modifications have not been clearly investigated in obese women, we evaluated the influences of menopausal status on anthropometric, hormonal and biochemical characteristics in selected groups of normal-weight and obese women. We studied 92 female outpatients: 24 normal-weight pre-menopausal (Pre-NW) [body mass index (BMI) 23.6±0.48, age 44.8±0.68], 24 normal-weight post-menopausal (Post-NW) (BMI 23.7±0.44, age 55.5±0.69), 24 obese pre-menopausal (pre-OB (BMI 32.3±0.45, age 44.6±0.75), 20 obese post-menopausal women (Post-OB) (BMI 32.9±0.57, age 55.2±0.82). All the subjects were non smokers and free from hypertension, diabetes or impaired glucose tolerance (IGT). Anthropometric parameters, body composition, 17 β-estradiol, LH, FSH, androstenedione, SHBG, testosterone and leptin were determined. Free androgen index (FAI) and insulin resistance index (HOMA) were calculated. In comparison with Pre-OB, Post-OB had higher values of waist circumferences (p

Original languageEnglish
Pages (from-to)648-653
Number of pages6
JournalJournal of Endocrinological Investigation
Volume27
Issue number7
Publication statusPublished - Jul 2004

Keywords

  • Androgens
  • Leptin
  • Menopause
  • Obesity
  • Visceral adiposity

ASJC Scopus subject areas

  • Endocrinology

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