Anthropometric, Metabolic and Molecular Determinants of Human Epidermal Growth Factor Receptor 2 Expression in Luminal B Breast Cancer

Patrizia Vici, Anna Crispo, Antonio Giordano, Luigi Di Lauro, Francesca Sperati, Irene Terrenato, Laura Pizzuti, Domenico Sergi, Marcella Mottolese, Claudio Botti, Maria Grimaldi, Immacolata Capasso, Giuseppe D'Aiuto, Maurizio Di Bonito, Flaviano Di Paola, Marcello Maugeri-Saccà, Maurizio Montella, Maddalena Barba

Research output: Contribution to journalArticle

Abstract

Genomic and trascriptomic profiling has recently contributed details to the characterization of luminal B breast cancer. We explored the contribution of anthropometric, metabolic, and molecular determinants to the multifaceted heterogeneity of this breast cancer subtype, with a specific focus on the association between body mass index (BMI), pre-treatment fasting glucose, hormone receptors, and expression of human epidermal growth factor receptor 2 (HER2). Extensively annotated specimens were obtained from 154 women with luminal B breast cancer diagnosed at two Italian comprehensive cancer centres. Participants' characteristics were descriptively analyzed overall and by HER2 status (positive vs. negative). BMI (

Original languageEnglish
Pages (from-to)1708-1712
Number of pages5
JournalJournal of Cellular Physiology
Volume230
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology
  • Medicine(all)

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    Vici, P., Crispo, A., Giordano, A., Lauro, L. D., Sperati, F., Terrenato, I., Pizzuti, L., Sergi, D., Mottolese, M., Botti, C., Grimaldi, M., Capasso, I., D'Aiuto, G., Bonito, M. D., Paola, F. D., Maugeri-Saccà, M., Montella, M., & Barba, M. (2015). Anthropometric, Metabolic and Molecular Determinants of Human Epidermal Growth Factor Receptor 2 Expression in Luminal B Breast Cancer. Journal of Cellular Physiology, 230(8), 1708-1712. https://doi.org/10.1002/jcp.24891