Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition

Annika Steffen, Matthias B. Schulze, Tobias Pischon, Thomas Dietrich, Esther Molina, Maria Dolores Chirlaque, Aurelio Barricarte, Pilar Amiano, J. Ramón Quirós, Rosario Tumino, Amalia Mattiello, Domenico Palli, Paolo Vineis, Claudia Agnoli, Gesthimani Misirli, Paolo Boffetta, Rudolf Kaaks, Sabine Rohrmann, H. Bas Bueno-de-Mesquita, Petra H M PeetersAnne M. May, Elizabeth A. Spencer, Naomi E. Allen, Sheila Bingham, Anne Tjønneland, Jytte Halkjær, Kim Overvad, Jakob Stegger, Jonas Manjer, Björn Lindkvist, Göran Hallmanns, Roger Stenling, Eiliv Lund, Elio Riboli, Carlos A. Gonzalez, Heiner Boeing

Research output: Contribution to journalArticlepeer-review


Background: Increasing evidence suggests that general obesity [measured by body mass index (BMI)] is positively associated with risk of esophageal adenocarcinoma (EAC). In contrast, previous studies have shown inverse relations with esophageal squamous cell carcinoma (ESCC). However, it is still unclear whether body fat distribution, particularly abdominal obesity, is associated with each type of esophageal cancer. Methods: We applied multivariable adjusted Cox proportional hazards regression to investigate the association between anthropometric measures and risk of EAC and ESCC among 346,554 men and women participating in the European Prospective Investigation into Cancer and Nutrition. All statistical tests were two sided. Results: During 8.9 years of follow-up, we documented 88 incident cases of EAC and 110 cases of ESCC. BMI, waist circumference, and waist-to-hip ratio (WHR) were positively associated with EAC risk [highest versus lowest quintile; relative risk (RR), 2.60; 95% confidence interval (95% CI), 1.23-5.51; Ptrend <0.01; RR, 3.07; 95% CI, 1.35-6.98; Ptrend <0.003; and RR, 2.12; 95% CI, 0.98-4.57; Ptrend <0.004]. In contrast, BMI and waist circumference were inversely related to ESCC risk, whereas WHR showed no association with ESCC. In stratified analyses, BMI and waist circumference were significantly inversely related to ESCC only among smokers but not among nonsmokers. However, when controlled for BMI, we found positive associations for waist circumference and WHR with ESCC, and these associations were observed among smokers and nonsmokers. Conclusion: General and abdominal obesity were associated with higher EAC risk. Further, our study suggests that particularly an abdominal body fat distribution might also be a risk factor for ESCC.

Original languageEnglish
Pages (from-to)2079-2089
Number of pages11
JournalCancer Epidemiology Biomarkers and Prevention
Issue number7
Publication statusPublished - Jul 2009

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


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