TY - JOUR
T1 - Anthropometry, physical activity, and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition
AU - Berrington De González, Amy
AU - Spencer, Elizabeth A.
AU - Bueno-De-Mesquita, H. Bas
AU - Roddam, Andrew
AU - Stolzenberg-Solomon, Rachel
AU - Halkjær, Jytte
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Clavel-Chapelon, Francoise
AU - Boutron-Ruault, Marie Christine
AU - Boeing, Heiner
AU - Pischon, Tobias
AU - Linseisen, Jakob
AU - Rohrmann, Sabine
AU - Trichopoulou, Antonia
AU - Benetou, Vassiliki
AU - Papadimitriou, Aristoteles
AU - Pala, Valeria
AU - Palli, Domenico
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Boshuizen, Hendriek C.
AU - Ocke, Marga C.
AU - Peeters, Petra H.
AU - Lund, Eiliv
AU - Gonzalez, Carlos A.
AU - Larrañaga, Nerea
AU - Martinez-Garcia, Carmen
AU - Mendez, Michelle
AU - Navarro, Carmen
AU - Quirós, J. Ramón
AU - Tormo, María José
AU - Hallmans, Göran
AU - Ye, Weimin
AU - Bingham, Sheila A.
AU - Khaw, Kay Tee
AU - Allen, Naomi
AU - Key, Tim J.
AU - Jenab, Mazda
AU - Norat, Teresa
AU - Ferrari, Pietro
AU - Riboli, Elio
PY - 2006/5
Y1 - 2006/5
N2 - Tobacco smoking is the only established risk factor for pancreatic cancer. Results from several epidemiologic studies have suggested that increased body mass index and/or lack of physical activity may be associated with an increased risk of this disease. We examined the relationship between anthropometry and physical activity recorded at baseline and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (n = 438,405 males and females age 19-84 years and followed for a total of 2,826,070 person-years). Relative risks (RR) were calculated using Cox proportional hazards models stratified by age, sex, and country and adjusted for smoking and self-reported diabetes and, where appropriate, height. In total, there were 324 incident cases of pancreatic cancer diagnosed in the cohort over an average of 6 years of follow-up. There was evidence that the RR of pancreatic cancer was associated with increased height [RR, 1.74; 95% confidence interval (95% CI), 1.20-2.52] for highest quartile compared with lowest quartile (Ptrend = 0.001). However, this trend was primarily due to a low risk in the lowest quartile, as when this group was excluded, the trend was no longer statistically significant (P = 0.27). A larger waist-to-hip ratio and waist circumference were both associated with an increased risk of developing the disease (RR per 0.1, 1.24; 95% CI, 1.04-1.48; Ptrend = 0.02 and RR per 10 cm, 1.13; 95% CI, 1.01-1.26; Ptrend = 0.03, respectively). There was a nonsignificant increased risk of pancreatic cancer with increasing body mass index (RR, 1.09; 95% CI, 0.95-1.24 per 5 kg/m2), and a nonsignificant decreased risk with total physical activity (RR, 0.82; 95% CI, 0.50-1.35 for most active versus inactive). Future studies should consider including measurements of waist and hip circumference, to further investigate the relationship between central adiposity and the risk of pancreatic cancer.
AB - Tobacco smoking is the only established risk factor for pancreatic cancer. Results from several epidemiologic studies have suggested that increased body mass index and/or lack of physical activity may be associated with an increased risk of this disease. We examined the relationship between anthropometry and physical activity recorded at baseline and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (n = 438,405 males and females age 19-84 years and followed for a total of 2,826,070 person-years). Relative risks (RR) were calculated using Cox proportional hazards models stratified by age, sex, and country and adjusted for smoking and self-reported diabetes and, where appropriate, height. In total, there were 324 incident cases of pancreatic cancer diagnosed in the cohort over an average of 6 years of follow-up. There was evidence that the RR of pancreatic cancer was associated with increased height [RR, 1.74; 95% confidence interval (95% CI), 1.20-2.52] for highest quartile compared with lowest quartile (Ptrend = 0.001). However, this trend was primarily due to a low risk in the lowest quartile, as when this group was excluded, the trend was no longer statistically significant (P = 0.27). A larger waist-to-hip ratio and waist circumference were both associated with an increased risk of developing the disease (RR per 0.1, 1.24; 95% CI, 1.04-1.48; Ptrend = 0.02 and RR per 10 cm, 1.13; 95% CI, 1.01-1.26; Ptrend = 0.03, respectively). There was a nonsignificant increased risk of pancreatic cancer with increasing body mass index (RR, 1.09; 95% CI, 0.95-1.24 per 5 kg/m2), and a nonsignificant decreased risk with total physical activity (RR, 0.82; 95% CI, 0.50-1.35 for most active versus inactive). Future studies should consider including measurements of waist and hip circumference, to further investigate the relationship between central adiposity and the risk of pancreatic cancer.
UR - http://www.scopus.com/inward/record.url?scp=33744722474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744722474&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-05-0800
DO - 10.1158/1055-9965.EPI-05-0800
M3 - Article
C2 - 16702364
AN - SCOPUS:33744722474
VL - 15
SP - 879
EP - 885
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 5
ER -