Abstract
Human glycolytic enzyme -enolase was associated with human diseases and with inflammation. An ELISA test was developed to measure anti - enolase AAE IgG and AAE IgA in the serum from patients affected by inflammatory diseases with the purpose to evaluate it as a novel diagnostic marker. 80 healthy blood donors and 194 paediatric patients affected by Juvenile idiopathic arthritis (JIA), celiac disease (CD), Crohn's Disease (CrD), hereditary periodic fever (HPF), and PFAPA syndrome were included in the study. HPF patients showed high levels of AAE antibodies, whereas JIA, CD, and CrD presented only partial results. Benign fevers such as PFAPA were almost negative for AAE Abs. These findings suggested that the genetic dysfunction of inflammasome associated with HPF could lead to the formation of AAE Abs that could be used for an early and easy diagnosis.
| Original language | English |
|---|---|
| Article number | 870214 |
| Journal | International Journal of Rheumatology |
| Volume | 2011 |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Anti-α -enolase antibodies in serum from pediatric patients affected by inflammatory diseases : Diagnostic and pathogenetic insights. / Pontillo, Alessandra; Di Toro, Nicola; Edomi, Paolo; Shadlow, A.; Ammadeo, A.; Gattorno, M.; Not, T.; Lepore, L.; Crovella, S.
In: International Journal of Rheumatology, Vol. 2011, 870214, 2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-α -enolase antibodies in serum from pediatric patients affected by inflammatory diseases
T2 - Diagnostic and pathogenetic insights
AU - Pontillo, Alessandra
AU - Di Toro, Nicola
AU - Edomi, Paolo
AU - Shadlow, A.
AU - Ammadeo, A.
AU - Gattorno, M.
AU - Not, T.
AU - Lepore, L.
AU - Crovella, S.
PY - 2011
Y1 - 2011
N2 - Human glycolytic enzyme -enolase was associated with human diseases and with inflammation. An ELISA test was developed to measure anti - enolase AAE IgG and AAE IgA in the serum from patients affected by inflammatory diseases with the purpose to evaluate it as a novel diagnostic marker. 80 healthy blood donors and 194 paediatric patients affected by Juvenile idiopathic arthritis (JIA), celiac disease (CD), Crohn's Disease (CrD), hereditary periodic fever (HPF), and PFAPA syndrome were included in the study. HPF patients showed high levels of AAE antibodies, whereas JIA, CD, and CrD presented only partial results. Benign fevers such as PFAPA were almost negative for AAE Abs. These findings suggested that the genetic dysfunction of inflammasome associated with HPF could lead to the formation of AAE Abs that could be used for an early and easy diagnosis.
AB - Human glycolytic enzyme -enolase was associated with human diseases and with inflammation. An ELISA test was developed to measure anti - enolase AAE IgG and AAE IgA in the serum from patients affected by inflammatory diseases with the purpose to evaluate it as a novel diagnostic marker. 80 healthy blood donors and 194 paediatric patients affected by Juvenile idiopathic arthritis (JIA), celiac disease (CD), Crohn's Disease (CrD), hereditary periodic fever (HPF), and PFAPA syndrome were included in the study. HPF patients showed high levels of AAE antibodies, whereas JIA, CD, and CrD presented only partial results. Benign fevers such as PFAPA were almost negative for AAE Abs. These findings suggested that the genetic dysfunction of inflammasome associated with HPF could lead to the formation of AAE Abs that could be used for an early and easy diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=84855272556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855272556&partnerID=8YFLogxK
U2 - 10.1155/2011/870214
DO - 10.1155/2011/870214
M3 - Article
C2 - 22007226
AN - SCOPUS:84855272556
VL - 2011
JO - International Journal of Rheumatology
JF - International Journal of Rheumatology
SN - 1687-9260
M1 - 870214
ER -