Anti-β-adrenoceptors autoimmunity causing 'idiopathic' arrhythmias and cardiomyopathy

Donatella Brisinda, Anna Rita Sorbo, Angela Venuti, Maria Pia Ruggieri, Raffaele Manna, Peter Fenici, Gerd Wallukat, Johan Hoebeke, Andrea Frustaci, Riccardo Fenici

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To determine the prevalence of anti-β-adrenoceptors autoantibodies (aβAA) in patients with idiopathic arrhythmias (IA) and to assess whether aβAA are predictive markers for concealed cardiomyopathy in such patients. Methods and Results: Sixty-seven patients (group 1) with IA [25 supraventricular (SVA) and 42 ventricular (VA)]; 14 patients (group 2) with suspected cardiomyopathy, 12 patients with definite cardiomyopathy (group 3); and 19 healthy controls (group 4) were tested with an enzyme immunoassay, using synthetic peptides corresponding to the second extracellular loop of the human β1- and β2-adrenoceptors. Endomyocardial biopsy was performed in 29 patients. As compared with group 4 [3/19 (15.7%)], anti-β1-adrenoceptor autoantibodies (aβ1AA) were more frequent in group-1 patients [38/67 (56.7%; P

Original languageEnglish
Pages (from-to)1345-1353
Number of pages9
JournalCirculation Journal
Volume76
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • β-adrenoceptors
  • Arrhythmia
  • Biopsy
  • Cardiomyopathy
  • Myocarditis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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