Anti-β2-glycoprotein I IgG antibodies from 1-year-old healthy children born to mothers with systemic autoimmune diseases preferentially target domain 4/5: Might it be the reason for their 'innocent' profile?

Laura Andreoli, Cecilia Nalli, Mario Motta, Gary L. Norman, Zakera Shums, Susan Encabo, Walter L. Binder, Monica Nuzzo, Micol Frassi, Andrea Lojacono, Tadej Avcin, Pier Luigi Meroni, Angela Tincani

Research output: Contribution to journalArticle

Abstract

Background: Anti-β2-glycoprotein-I (anti- β2GPI) were demonstrated to be pathogenic in the antiphospholipid syndrome (APS). However, they can be detected in patients with no features of APS, especially those affected by systemic autoimmune diseases (SAD), and so in healthy children. It has been suggested that anti-β2GPI against domain 1 (D1) associate with thrombosis, while those recognising domain 4/5 (D4/5) are present in nonthrombotic conditions. Objective: To evaluate the fine specificity of anti- β2GPI in adults and infants. Methods: Three groups were examined - group A: 57 1-year-old healthy children born to mothers with SAD; group B: 33 children with atopic dermatitis; group C: 64 patients with APS. Subjects were selected based on positive anti-β2GPI IgG results. Serum samples were tested for anti-β2GPI IgG D1 and D4/5 using research ELISAs containing recombinant β2GPI domain antigens. Results: Children (A and B) displayed preferential IgG reactivity for D4/5, whereas patients with APS were mainly positive for D1. No thrombotic events were recorded in groups A and B. Conclusions: The specificity for D4/5 suggests that anti-β2GPI IgG production in children born to mothers with SAD is a process neither linked to systemic autoimmunity nor related to the maternal autoantibody status. This unusual fine specificity might, at least partially, account for the 'innocent' profile of such antibodies.

Original languageEnglish
Pages (from-to)380-383
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume70
Issue number2
DOIs
Publication statusPublished - Feb 2011

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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