Anti-16-kilodalton mycobacterial protein immunoglobulin M levels in healthy but purified protein derivative-reactive children decrease after chemoprophylaxis

Guido Sireci, Francesco Dieli, Diana Di Liberto, Simona Buccheri, Marco Pio La Manna, Francesco Scarpa, Pasquale Macaluso, Amelia Romano, Lucina Titone, Paola Di Carlo, Mahavir Singh, Jurayi Ivanyi, Alfredo Salerno

Research output: Contribution to journalArticlepeer-review

Abstract

Serum responses against Mycobacterium tuberculosis HSP16 were determined for children with tuberculosis (TB) and for healthy purified protein derivative (PPD)-positive and PPD-negative children. Immunoglobulin G (IgG) and IgM responses were higher for TB patients than for other groups. After chemotherapy, IgM and IgG responses decreased for TB patients and PPD-positive subjects. Monitoring of anti-M tuberculosis HSP16 responses could assist in the management of pediatric TB.

Original languageEnglish
Pages (from-to)1231-1234
Number of pages4
JournalClinical and Vaccine Immunology
Volume14
Issue number9
DOIs
Publication statusPublished - Sep 2007

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

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